Positive direct antiglobulin test in COVID-19 patients: Decision-making process

Autor: Pascale Saussoy, J. Cabo, Véronique Deneys, A. Brochier, L. Capirchio, B. Delire, M.-A. van Dievoet
Přispěvatelé: UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de biologie hématologique, UCL - (SLuc) Service de gastro-entérologie
Rok vydání: 2021
Předmět:
elution
Clinical Biochemistry
030204 cardiovascular system & hematology
Serology
Ag
Antigen
0302 clinical medicine
DAT
Direct Antiglobulin Test
PCR
Polymerase Chain Reaction
Direct antiglobulin test
RBCs
Red Blood Cells
IAS
Irregular Antibody Screening
biology
Hematology
CRP
C-Reactive Protein
IAT
Indirect Antiglobulin Test
Coombs Test
COVID-19
Coronavirus Disease 2019
Antibody
Nl
normal
2019-20 coronavirus outbreak
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
ECMO
Extracorporeal Membrane Oxygenation
Coombs direct
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Context (language use)
AHG
Anti-Human Globulin
Ab
Antibody
direct antiglobulin test
élution
Article
03 medical and health sciences
AIHA
Autoimmune Haemolytic Anaemia
IAHA
Immuno-Allergic Haemolytic Anaemia
ICU
Intensive Care Unit
SOP
Standard Operating Procedure
medicine
Humans
Blood Transfusion
Intensive care medicine
transfusion
SARS-CoV-2
business.industry
Transfusion
Biochemistry (medical)
COVID-19
Elution
SARS-CoV-2
Severe Acute Respiratory Syndrome Coronavirus 2
CAS
Cold Agglutinin Syndrome
biology.protein
business
030215 immunology
Zdroj: Transfusion Clinique et Biologique
Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine, Vol. 28, no.4, p. 414-419 (2021)
ISSN: 1246-7820
DOI: 10.1016/j.tracli.2021.05.010
Popis: In this unprecedented crisis of severe acute respiratory syndrome coronavirus 2 and its associated coronavirus disease 2019 (COVID-19), polymerase chain reaction and then serological testing platforms have been massively developed to face the important screening demand. Polymerase chain reaction and serological testing platforms are not the only actors impacted by the crisis, transfusion services are facing important difficulties. A positive direct antiglobulin test is frequently observed for patients encountering COVID-19. Patients with severe symptoms may develop anaemia and become good candidates for blood transfusions. The interpretation of a positive direct antiglobulin test for patients recently transfused and suffering from COVID-19 is complex. The differentiation between COVID-19 induced antibodies and possible associated transfusion alloantibodies is therefore crucial. In this context, the elution technique incorporated in an appropriate decision-making process plays its full role. This intricate topic is presented through a case report followed by literature review and finally decision-making process for COVID-19 patients necessitating red blood cells administration.
Databáze: OpenAIRE
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