Henle Loop Basement Membrane as Initial Site for Randall Plaque Formation
| Autor: | Carmelo Libetta, Alfredo La Fianza, Vincenzo Sepe, Gabriella Adamo, Grazia Soccio, Antonio Dal Canton, Maria G. Giuliano |
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| Rok vydání: | 2006 |
| Předmět: |
Basement membrane
Stone formation Calcium Oxalate business.industry Urinary stone Anatomy Basement Membrane Phosphates Calcium Dietary Kidney Tubules Proximal Kidney Calculi Urodynamics Mucoproteins medicine.anatomical_structure Nephrology Uromodulin Calcium concentration Loop of Henle Biophysics Chemical Precipitation Humans Medicine business |
| Zdroj: | American Journal of Kidney Diseases. 48:706-711 |
| ISSN: | 0272-6386 |
| Popis: | Since the early description of Randall plaques in 1937, studies of the pathogenesis of stone formation mainly focused on the chemistry involving salt precipitation and crystallization, rather than tubular and interstitial medullar mechanisms of calcium concentration and supersaturation. In 2003, Bushinsky published a suggestive and inspiring sequence of events aimed to show that the basement membrane of the thin limb of the loop of Henle can be the first site of nucleation, as recently shown by the impressive work by Evan et al. The aim of this minireview is to verify the consistency of the Evan and Bushinsky theory with the current literature in the field. |
| Databáze: | OpenAIRE |
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