Cardiac Denervation for Arrhythmia Treatment with Transesophageal Ultrasonic Strategy in Canine Models
| Autor: | Zhigang Wang, Jun Qian, Bo Xiong, Dichuan Liu, Shunkang Rong, Gang Yang, Changming Deng, Jie Tan, Yuwen Huang, Dengqing Zhang, Jing Huang, Que Zhu, Haitao Ran, Yuanqing Yao, Shimin Deng |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Acoustics and Ultrasonics medicine.medical_treatment Stellate Ganglion Biophysics 030204 cardiovascular system & hematology QT interval 03 medical and health sciences Dogs 0302 clinical medicine In vivo Internal medicine medicine Animals Radiology Nuclear Medicine and imaging 030212 general & internal medicine Esophagus Ultrasonography Interventional Radiological and Ultrasound Technology business.industry Arrhythmias Cardiac Ablation Disease Models Animal Catheter medicine.anatomical_structure Cardiac denervation Stellate ganglion Cardiology High-Intensity Focused Ultrasound Ablation Ultrasonic sensor business |
| Zdroj: | Ultrasound in Medicine & Biology. 45:490-499 |
| ISSN: | 0301-5629 |
| DOI: | 10.1016/j.ultrasmedbio.2018.10.013 |
| Popis: | Stellate ganglion (SG) modification has been investigated for arrhythmia treatment. In this study, transesophageal SG imaging and intervention were explored using a homemade 30F integrated focused ultrasonic catheter in healthy mongrel canines in vivo. Anatomic details of SGs were ultrasonically imaged and evaluated. SG had a heterogeneous echoic structure and characteristic profiles sketched by hyper-echoic outlines in an ultrasonogram. Left SGs in the experimental group were successfully ablated through the esophagus under ultrasonic guidance provided by the catheter itself. Two weeks after the ablation, the QT and QTc of the experimental group decreased compared with those of the sham group and at baseline (both p values < 0.001). Histologic examination revealed that left SGs were destroyed. No major complications were observed. This approach may be further explored as a method for ganglia remodeling evaluation and as a strategy of ganglia modification for arrhythmia and for other diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|