Co-expression of NF-κB-p65 and phosphorylated NF-κB-p105 is associated with poor prognosis in surgically resectable non-small cell lung cancer
| Autor: | Chao Li, Cheng Huang, Qian Miao, Haipeng Xu, Gen Lin, Wu Zhuang, Dan Hu, Yun-jian Huang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
non‐small cell lung cancer
Adult Male 0301 basic medicine Poor prognosis Lung Neoplasms p105 Adenocarcinoma 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Text mining Carcinoma Non-Small-Cell Lung Biomarkers Tumor Humans Medicine Prospective Studies Phosphorylation Lung cancer Aged p65 business.industry Transcription Factor RelA NF-kappa B p50 Subunit NF-κB Original Articles Cell Biology Middle Aged Prognosis medicine.disease Survival Analysis Gene Expression Regulation Neoplastic Nf κb p65 030104 developmental biology chemistry 030220 oncology & carcinogenesis Carcinoma Squamous Cell Cancer research Molecular Medicine Original Article Female Non small cell business Positive staining nuclear factor‐kappa b Signal Transduction |
| Zdroj: | Journal of Cellular and Molecular Medicine |
| ISSN: | 1582-1838 |
| DOI: | 10.1111/jcmm.13476 |
| Popis: | Nuclear factor‐kappa B (NF‐κB) as a prognostic marker remains unclear in non‐small cell lung cancer (NSCLC). Here, we studied NF‐κB‐p65 (p65) expression and phosphorylated NF‐κB‐p105 (p‐p105) expression in NSCLC and correlated the finding with overall survival (OS) and clinicopathological features. A total of 186 archival samples from patients with surgically resectable NSCLC were probed with p65 and p‐p105 (Ser 932). The p65‐positive expression and p‐p105‐positive expression were defined as distinct nuclear p65 and cytoplasmic p‐p105 labelling in at least 1% of tumour cells, respectively. The positive staining of p65 alone, p‐p105 alone and co‐expression of p65 and p‐p105 were observed in 61 (32.8%), 90 (48.4%) and 35 (18.8%) patients, respectively. Co‐expression of p65 and p‐p105 but not of either p65 or p‐p105 alone was associated with a poor prognosis. Patients with co‐expression of p65 and p‐p105 had a shorter OS than others, median OS 26.5 months versus 64.1 months, HR 1.85 (95% CI: 1.18–2.91), P = 0.007. There was no statistically significant association between clinicopathological characteristics and either p65 or p‐p105 alone or co‐expression of p65 and p‐p105. This indicates that co‐expression of p65 and p‐p105 was a poor prognostic factor, and pathologic studies of NF‐κB expression could include multiple pathway components in NSCLC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text