Healing activity of Casearia sylvestris Sw. in second-degree scald burns in rodents
| Autor: | Letícia Nava Trombini, Miriéle Cristina Ferraz, Décio Luis Portella, Adriana Carolina Werner, Marli Gerenutti, José Carlos Cogo, Rafaela Rodrigues, Yoko Oshima-Franco, Robson Vicente Machado de Oliveira, Evandro Pedro de Campos, Norberto Aranha |
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| Rok vydání: | 2015 |
| Předmět: |
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medicine.medical_specialty Hot Temperature Casearia Antivenom Anti-Inflammatory Agents Venom Jararacussu General Biochemistry Genetics and Molecular Biology Mice Casearia sylvestris Crotalid Venoms Scalding Animals Medicine Bothrops Rats Wistar Skin Medicine(all) Analgesics Wound Healing biology Traditional medicine Biochemistry Genetics and Molecular Biology(all) Antivenins Plant Extracts business.industry Biofilm Acetobacter xylinum General Medicine biology.organism_classification medicine.disease Surgery Bothrops jararacussu Neuroprotective Agents Burns business Wound healing Research Article |
| Zdroj: | BMC Research Notes |
| ISSN: | 1756-0500 |
| DOI: | 10.1186/s13104-015-1251-4 |
| Popis: | Background Every year thousands of people are victims of burns, mainly scald burns. Many of these victims have small size wounds and superficial partial thickness and do not seek specialized medical care. As in Brazil Casearia sylvestris Sw., popularly known as guaçatonga is widely used for its analgesic, antiseptic and anti-inflammatory activities, this study sought to evaluate the effects of its hydroalcoholic extract in healing process of burns injuries. Methods The obtained extract was validated applying a thin layer chromatography and sophisticated validation method using Bothrops jararacussu snake venom that is necrotic and inflammatory, and by which guaçatonga extract was able to neutralize the irreversible neuromuscular blockade induced by the venom. After induction of the scald injury, the animals were treated daily with saline solution spray; spray containing extract; biofilm; or biofilm impregnated with extract. Results Significant differences were observed between the four groups studied considering: extension of the healing area, neovascularization, fibroblast proliferation, and epithelialization. Conclusion The anti-inflammatory and bactericidal effects of C. sylvestris Sw. suggests a potential therapeutic benefit in the treatment of inflammatory conditions in second-degree scald burn injuries, as well as, counteracting against the in vitro paralysis induced by B. jararacussu venom. |
| Databáze: | OpenAIRE |
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