Antidepressant response and intolerance to SSRI is not influenced by G-protein β3 subunit gene C825T polymorphism in Japanese major depressive patients
| Autor: | Gaku Okugawa, Masaki Kato, Masataka Wakeno, Tsuyoshi Fukuda, Junichi Azuma, Yoshiteru Takekita, Alessandro Serretti, Yuka Hosoi, Toshihiko Kinoshita |
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| Přispěvatelé: | Kato M., Wakeno M., Okugawa G., Fukuda T., Takekita Y., Hosoi Y., Azuma J., Kinoshita T., Serretti A. |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Fluvoxamine behavioral disciplines and activities Japan Internal medicine mental disorders medicine Humans Serotonin Uptake Inhibitors Biological Psychiatry Psychiatric Status Rating Scales Pharmacology Depressive Disorder Major Polymorphism Genetic digestive oral and skin physiology Hamilton Rating Scale for Depression Middle Aged Heterotrimeric GTP-Binding Proteins Paroxetine Antidepressive Agents Endocrinology 5-HTTLPR Antidepressant Female Psychology Selective Serotonin Reuptake Inhibitors Pharmacogenetics medicine.drug GNB3 |
| Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry. 32:1041-1044 |
| ISSN: | 0278-5846 |
| DOI: | 10.1016/j.pnpbp.2008.01.019 |
| Popis: | The G-protein beta3 subunit (GNB3) gene is a key modulator of signal transduction and is a major candidate for SSRIs response. The aim of the present study is to test a possible effect of the C825T polymorphism on the antidepressant response and intolerance to selective serotonin reuptake inhibitors (SSRIs) in 146 Japanese samples with major depression treated with paroxetine or fluvoxamine for 6 weeks. The severity of depression symptom was assessed using the 21-item Hamilton Rating Scale for Depression (HAM-D) and adverse drug reactions were evaluated bi-weekly. No association with SSRIs treatment response was observed in 107 completers also including HAM-D baseline scores, SSRI type or/and 5-HTTLPR variants in the model as covariates. Furthermore, no significant association could be observed with intolerance to SSRIs in the whole subjects. The result suggests that C825T variants of GNB3 cannot play a major role as a predictor of treatment response as well as intolerance to SSRIs in Japanese patients with major depression. |
| Databáze: | OpenAIRE |
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