Increased susceptibility toStrongyloides venezuelensisin mice due toMycobacterium bovisco-infection which modulates production of Th2 cytokines
| Autor: | Ana Paula Fernandes, M. A. Vicentini, M. L. De Paula, Michele M. Barsante, Caio César de Souza Alves, Juliana da Silva Brandi, Ana Paula Ferreira, Alyria Teixeira Dias, Lívia L. Alves, Arturene M. L. Carmo, Maria Aparecida de Souza, Deborah Negrão-Corrêa, Henrique Couto Teixeira |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_treatment Population Microbiology Mycobacterium tuberculosis Feces Interferon-gamma Mice Th2 Cells Immune system Strongyloides medicine Animals Helminths Rats Wistar education Lung Parasite Egg Count Mice Inbred BALB C Mycobacterium Infections Mycobacterium bovis education.field_of_study biology medicine.disease biology.organism_classification Interleukin-10 Rats Intestines Infectious Diseases Strongyloidiasis Cytokine Immunology Cytokines Animal Science and Zoology Parasitology Disease Susceptibility |
| Zdroj: | Parasitology. 136:1357-1365 |
| ISSN: | 1469-8161 0031-1820 |
| DOI: | 10.1017/s0031182009990655 |
| Popis: | SUMMARYAn estimated quarter of the world's population possesses an infection caused by gastrointestinal nematodes, which induce a Th2 type immune response. Concomitant infection of nematodes withMycobacterium tuberculosis, which induces a predominantly Th1 type response, is very frequent in tropical and subtropical regions. This study examined immune responses of BALB/c mice infected withStrongyloides venezuelensisand then co-infected withMycobacterium bovis. The number of worms in the intestine, eggs in feces, cytokine production in lungs and intestine and the expression of CD80, CD86, CTLA-4 and CD28 cell markers on pulmonary cells were analysed. Our results indicate that co-infected mice had an increased parasite burden, which correlates with elevated IFN-γ and IL-10 cytokine production and decreased IL-4 and IL-13. Moreover, decreased expression of CD80 and increased expression of CTLA-4 were observed in co-infected mice. Our data point out that susceptibility toStrongyloides venezuelensisinfection is increased byMycobacterium bovisco-infection, resulting in higher parasite survival. |
| Databáze: | OpenAIRE |
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