Is There a Hidden Burden of Disease as a Result of Epigenetic Epithelial-to-Mesenchymal Transition Following Chlamydia trachomatis Genital Tract Infection?
| Autor: | Andrew W Horne, Heather Flanagan, Patrick J Horner |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Infertility
Epithelial-Mesenchymal Transition cervical cancer Uterine Cervical Neoplasms Chlamydia trachomatis Disease medicine.disease_cause Reproductive Tract Infections Epigenesis Genetic Cost of Illness Pregnancy Pelvic inflammatory disease medicine Humans Immunology and Allergy Chlamydia Ovarian Neoplasms Ectopic pregnancy business.industry Chlamydia Infections Tubal factor infertility medicine.disease Pregnancy Ectopic ovarian cancer Infectious Diseases Pelvic inflammatory disease (PID) pelvic inflammatory disease (PID) Immunology ectopic pregnancy Female infertility business epithelial-to-mesenchymal transition (EMT) Pelvic Inflammatory Disease |
| Zdroj: | Horner, P J, Flanagan, H & Horne, A W 2021, ' Is there a hidden burden of disease as a result of epigenetic epithelial-to-mesenchymal transition following Chlamydia trachomatis genital tract infection? ', Journal of Infectious Diseases, vol. 224, no. Supplement 2, pp. S128-S136 . https://doi.org/10.1093/infdis/jiab088 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jiab088 |
| Popis: | Chlamydia trachomatis (CT), the most common bacterial sexually transmitted infection worldwide, has been widely researched for its involvement in many disease pathologies in the reproductive tract, including pelvic inflammatory disease, ectopic pregnancy, and tubal factor infertility. Recent findings, through the efforts to understand the pathogenesis of CT, suggest that CT can induce the process of epithelial-to-mesenchymal transition (EMT) through epigenetic changes in the epithelium of the female reproductive tract. This literature review aims to analyze the evidence for CT’s ability to promote EMT and to pinpoint the areas that merit further investigation. |
| Databáze: | OpenAIRE |
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