3R coordination by Fanconi anemia proteins
| Autor: | Filippo Rosselli, Jean-Hugues Guervilly, Massimo Bogliolo, Jean Antoine Dugas du Villard, Gaëtane Macé |
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| Rok vydání: | 2005 |
| Předmět: |
Genome instability
DNA Replication Fanconi anemia complementation group C DNA Repair DNA repair DNA damage Cell Cycle Proteins Biology Biochemistry Genomic Instability Fanconi anemia medicine Humans Gene Genetics Cell Cycle Bone marrow failure DNA replication Genetic Diseases Inborn Nuclear Proteins General Medicine Syndrome medicine.disease Fanconi Anemia Complementation Group Proteins DNA-Binding Proteins Fanconi Anemia Gene Expression Regulation DNA Damage |
| Zdroj: | Biochimie. 87(7) |
| ISSN: | 0300-9084 |
| Popis: | Fanconi anemia (FA) is a recessive cancer prone syndrome featuring bone marrow failure and hypersensitivity to DNA crosslinks. Nine FA genes have been isolated so far. The biochemical function(s) of the FA proteins remain(s) poorly determined. However, a large consensus exists on the evidence that, to cope with DNA cross-links, a cell needs a functional FA pathway. In this review, we resume current understanding of how the FA pathway works in response to DNA damage and how it is integrated in a complex network of proteins involved in the maintenance of the genetic stability. |
| Databáze: | OpenAIRE |
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