Studies on circulating antibody against carcinoembryonic antigen (CEA) and CEA-like antigen in cancer patients
| Autor: | Katsuyuki Nakajima, Yasuaki Ura, Masanari Hamazu, Takeshi Watanabe, Masao Ishida, Yukio Ochi |
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| Rok vydání: | 1985 |
| Předmět: |
Male
Cancer Research Antibodies Neoplasm Breast Neoplasms Immunoglobulin G Epitopes Carcinoembryonic antigen Lewis Blood Group Antigens Affinity chromatography Antigen Antigens Neoplasm medicine Humans neoplasms Aged Autoantibodies Glycoproteins biology Chemistry Rectal Neoplasms Liver Neoplasms Autoantibody Cancer Antibodies Monoclonal respiratory system Middle Aged medicine.disease Molecular biology digestive system diseases Carcinoembryonic Antigen Oncology Polyclonal antibodies Immunology Colonic Neoplasms biology.protein Immunologic Techniques Female Antibody Cell Adhesion Molecules |
| Zdroj: | Cancer letters. 25(3) |
| ISSN: | 0304-3835 |
| Popis: | Characteristics of auto-antibodies for carcinoembryonic antigen (CEA) detected in sera from 3 cancer patients (2 colorectal and 1 breast cancer) were examined. The antibodies belonged to polyclonal immunoglobulin G (IgG). The binding of auto-antibodies with the labeled CEA was inhibited by not only the unlabeled CEA but also NCA-2 (feces and meconium). However, no binding with NCA was observed. Among these auto-antibodies the antibody directed against blood group Lewis determinants which are known to be present in many purified CEA preparations was not found. Previously we had suggested that CEA, NCA-2 and NCA may contain immune determinant in common with alpha 1-acid glycoprotein (AG). These auto-antibodies showed significantly enhanced reactivity for the labeled CEA preparation after purification by anti-AG affinity chromatography in spite of no immunological reaction with AG. These results suggest that auto-antibodies are raised against the common antigenic determinants of both CEA and NCA-2 which do not exist in NCA. These antibodies might be directed to common amino acid sequence shared by CEA and NCA-2, though not excluding the carbohydrate moiety. We surveyed about 500,000 cancer patients but could find only 3 patients who showed a difference in the values of CEA by the indirect and direct method. Thus, the existence of this type auto-antibody to CEA in cancer patients is a rare phenomenon. |
| Databáze: | OpenAIRE |
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