Obesity-Related Asthma: Immune Regulation and Potential Targeted Therapies
| Autor: | Xuewa Guan, Guoqiang Wang, Junying Lu, Lingxin Xiong, Ziyan Wang, Nan Ran, Jie Ma, Ruipeng Zheng, Yuze Yuan, Chao Zhang, Yingqiao Guo, Keyong Fang, Fang Wang, Jingtong Zheng, Zhiqiang Pang |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
lcsh:Immunologic diseases. Allergy Immunology Review Article Bioinformatics Immunomodulation 03 medical and health sciences medicine Immunology and Allergy Humans Immune Regulators Molecular Targeted Therapy Obesity Asthma Metabolic Syndrome business.industry Immune regulation Lipid metabolism General Medicine Immune modulation medicine.disease Lipid Metabolism 030104 developmental biology Adipose Tissue Treatment strategy Metabolic syndrome business lcsh:RC581-607 |
| Zdroj: | Journal of Immunology Research, Vol 2018 (2018) Journal of Immunology Research |
| ISSN: | 2314-7156 |
| Popis: | Obesity, one of the most severe public health problems of the 21st century, is a common metabolic syndrome due to excess body fat. The incidence and severity of obesity-related asthma have undergone a dramatic increase. Because obesity-related asthma is poorly controlled using conventional therapies, alternative and complementary therapies are urgently needed. Lipid metabolism may be abnormal in obesity-related asthma, and immune modulation therapies need to be investigated. Herein, we describe the immune regulators of lipid metabolism in obesity as well as the interplay of obesity and asthma. These lay the foundations for targeted therapies in terms of direct and indirect immune regulators of lipid metabolism, which ultimately help provide effective control of obesity-related asthma with a feasible treatment strategy. |
| Databáze: | OpenAIRE |
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