Primary Gleason pattern upgrading in contemporary patients with D'Amico low-risk prostate cancer: implications for future biomarkers and imaging modalities
| Autor: | Sami-Ramzi Leyh-Bannurah, Hans Heinzer, Zhe Tian, Hartwig Huland, Paolo Dell'Oglio, Hiba Abou-Haidar, Lars Budäus, Pierre I. Karakiewicz, Markus Graefen, Jonas Schiffmann |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Urology medicine.medical_treatment 030232 urology & nephrology Logistic regression Risk Assessment Imaging modalities 03 medical and health sciences Prostate cancer 0302 clinical medicine Predictive Value of Tests Internal medicine Biomarkers Tumor medicine Humans Watchful Waiting Contraindication Aged Retrospective Studies Gynecology Prostatectomy business.industry Prostatic Neoplasms Middle Aged Nomogram medicine.disease 030220 oncology & carcinogenesis Cohort Neoplasm Grading business Primary Gleason Pattern |
| Zdroj: | BJU International. 119:692-699 |
| ISSN: | 1464-4096 |
| DOI: | 10.1111/bju.13570 |
| Popis: | Objective To retrospectively assess the rate of high-grade primary Gleason upgrading (HGPGU) to primary Gleason pattern 4 or 5 in a contemporary cohort of patients with D'Amico low-risk prostate cancer including those who fulfilled Prostate Cancer Research International Active Surveillance (PRIAS) criteria, and to develop a tool for HGPGU prediction. HGPGU is a contraindication in most active surveillance (AS) and focal therapy protocols. Patients and Methods In all, 10 616 patients with localised prostate cancer were treated at a high-volume European tertiary care centre from 2010 to 2015 with radical prostatectomy. Analyses were restricted to 1 819 patients with D'Amico low-risk prostate cancer (17.1%) with prostate-specific antigen (PSA) levels of |
| Databáze: | OpenAIRE |
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