Indocyanine Green-holo-Transferrin Nanoassemblies for Tumor-Targeted Dual-Modal Imaging and Photothermal Therapy of Glioma
| Autor: | Chengbo Liu, Xianyuan Xia, Zonghai Sheng, Hairong Zheng, Pan Wang, Xiaobing Wang, Mingting Zhu, Yali Jia, Xin Liu, Dehong Hu |
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| Rok vydání: | 2017 |
| Předmět: |
Indocyanine Green
Fluorescence-lifetime imaging microscopy Materials science genetic structures Theranostic Nanomedicine Brain tumor Photoacoustic imaging in biomedicine Nanotechnology macromolecular substances 02 engineering and technology 010402 general chemistry environment and public health 01 natural sciences chemistry.chemical_compound Glioma medicine Humans General Materials Science Holo transferrin Transferrin Photothermal therapy 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences chemistry Cancer research Nanoparticles 0210 nano-technology Indocyanine green |
| Zdroj: | ACS Applied Materials & Interfaces. 9:39249-39258 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.7b14076 |
| Popis: | Active-targeted cancer imaging and therapy of glioma has attracted much attention in theranostic nanomedicine. As a promising tumor-targeting ligand, holo-transferrin (holo-Tf) has been applied for enhancing delivery of nanotheranostics. However, holo-Tf-based nanoassemblies for active targeting mediated multimodal imaging and therapeutics have not been previously reported. Here, we develop a one-step method for the preparation of holo-Tf-indocyanine green (holo-Tf-ICG) nanoassemblies for fluorescence (FL) and photoacoustic (PA) dual-modal imaging and photothermal therapy (PTT) of glioma. The nanoassemblies are formed by hydrophobic interaction and hydrogen bonds between holo-Tf and ICG, which exhibit excellent active tumor-targeting and high biocompability. The brain tumor with highly expressed Tf receptor can be clearly observed with holo-Tf-ICG nanoassemblies base on FL and PA dual-modal imaging in subcutaneous and orthotopic glioma models. Under the near-infrared laser irradiation, the holo-Tf-ICG nanoassemblies accumulated in tumor regions can efficiently convert laser energy into hyperthermia for tumor ablation. The novel theranostic nanoplatform holds great promise for precision diagnosis and treatment of glioma. |
| Databáze: | OpenAIRE |
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