Sehgal index: A new index and its comparison with other complete blood count-based indices for screening of beta thalassemia trait in a tertiary care hospital
| Autor: | Tina Dadu, Kunal Sehgal, Preeti Mansukhani, Shanaz Khodaiji, Meher Irani |
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| Rok vydání: | 2015 |
| Předmět: |
Microbiology (medical)
Adult Male Pediatrics medicine.medical_specialty complete blood count Adolescent Thalassemia Youden's J statistic lcsh:QR1-502 Sensitivity and Specificity lcsh:Microbiology Pathology and Forensic Medicine Tertiary Care Centers Young Adult lcsh:Pathology medicine Humans Mass Screening Sehgal index Prospective Studies Prospective cohort study Child Mass screening Aged Retrospective Studies Aged 80 and over iron deficiency anemia medicine.diagnostic_test business.industry Diagnostic Tests Routine Beta thalassemia trait beta-Thalassemia Complete blood count Beta thalassemia Infant Retrospective cohort study General Medicine Middle Aged medicine.disease Blood Cell Count Iron-deficiency anemia ROC Curve mentzers index Child Preschool Female business lcsh:RB1-214 |
| Zdroj: | Indian Journal of Pathology and Microbiology, Vol 58, Iss 3, Pp 310-315 (2015) |
| ISSN: | 0974-5130 |
| Popis: | Introduction: Beta thalassemia trait (BTT) must be differentiated from iron deficiency anemia to avoid unnecessary iron therapy and for the prevention of thalassemia major by genetic counseling. In a tertiary care hospital, it is vital that the screening tool is not only sensitive but also specific so as to be cost effective and save time. Aim: The aim of this study was to evaluate the new Sehgal index and compare it to existing complete blood count-based indices for the best combination of sensitivity and specificity to predict BTT. Materials and Methods: Study was done in 2 phases - Phase 1: A retrospective analysis of 1022 consecutive high-performance liquid chromatography (HPLC) cases from July 2008 to June 2011. Phase 2: A prospective analysis of 973 consecutive HPLC cases from July 1, 2011 to June 10, 2013 was done to confirm the results of Phase 1 and the applicability of the new Sehgal index. Results: Prevalence of BTT was 28.8% (294/1022) and 25.39% (247/973) in Phase 1 and Phase 2, respectively. Receiver operating characteristic-area under the curve and Youden index was highest for new Sehgal index, followed by Mentzers index |
| Databáze: | OpenAIRE |
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