IMPAIRED ABSORPTION OF CHLORPROMAZINE IN RATS GIVEN TRIHEXYPHENIDYL
| Autor: | Leonor Rivera-Calimlim |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Trihexyphenidyl Chlorpromazine Absorption (skin) In Vitro Techniques Intestinal absorption Oral administration Internal medicine medicine Animals Intestinal Mucosa Brain Chemistry Pharmacology Gastric emptying Chemistry Stomach hemic and immune systems Metabolism Rats Endocrinology medicine.anatomical_structure Intestinal Absorption Liver Depression Chemical lipids (amino acids peptides and proteins) Research Article medicine.drug |
| Zdroj: | British Journal of Pharmacology. 56:301-305 |
| ISSN: | 0007-1188 |
| DOI: | 10.1111/j.1476-5381.1976.tb07642.x |
| Popis: | 1 The absorption and tissue distribution of orally administered [14C]-chlorpromazine (CPZ) were compared in trihexyphenidyl (THP; Artane)-treated and control rats. 2 Total radioactivity (CPZ) in the plasma and brain of rats treated with THP was significantly lower whereas total radioactivity in the stomach was significantly higher than in rats not previously treated with THP. 3 Gastric emptying in rats treated with THP was significantly delayed as measured by gastric clearance of a marker [14C]-polyethylene glycol. 4 Transport of [14C]-CPZ in everted sacs was not affected by treatment with THP. 5 Metabolism of [14C]-CPZ by liver homogenates was not affected by treatment with THP. 6 The relationship of delayed gastric emptying in THP-treated rats and their lower plasma and brain levels of [14C]-CPZ after oral administration is discussed. |
| Databáze: | OpenAIRE |
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