Suppression of methionine-induced colon injury of young rats by cysteine and N-acetyl-L-cysteine
| Autor: | Dušan Mitrović, Marija Stojanović, Milica Labudovic Borovic, Teja Šćepanović, Živana Milićević, Ivana M. Lalić, Vuk Šćepanović, Sanja Despotović, Ljiljana Šćepanović, Radomir Šćepanović, Slobodan Ilic, Sunčica Borozan, Dušan Todorović, Vesna Dragutinović, Dragan Djuric |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Hyperhomocysteinemia medicine.medical_specialty Muscularis mucosae Clinical chemistry Colon Clinical Biochemistry Biology medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound Colonic Diseases Methionine Internal medicine medicine Animals Rats Wistar Molecular Biology Lamina propria Morphometry Cell Biology General Medicine medicine.disease 3. Good health Acetylcysteine Rats 030104 developmental biology medicine.anatomical_structure Endocrinology Biochemistry chemistry Catalase Oxidative stress biology.protein Rat Cysteine |
| Zdroj: | Molecular and Cellular Biochemistry |
| ISSN: | 1573-4919 |
| Popis: | Changes in the methionine metabolism can cause a state called hyperhomocysteinemia, inducing oxidative stress in the gut. The production of free radicals is important in the colon damage caused by methionine. This study aimed at evaluating the effect of the use of l-cysteine and N-acetyl-l-cysteine on the colon morphometry of young rats treated with methionine. A total number of 32 male rats were distributed in a randomized experimental design in 4 groups: control group treated with saline; methionine group; cysteine + methionine group, and N-acetyl-l-cysteine + methionine group. After 21 days of treatment, rats were sacrificed and the colon samples were taken for histological and biochemical analysis. Methionine load increased depth of crypts, the lamina muscularis mucosae thickness, the mucosal height, and the number of cells in lamina propria (p |
| Databáze: | OpenAIRE |
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