Fibroblast growth factor 8 is expressed at higher levels in lactating human breast and in breast cancer
| Autor: | S Shousha, C L Johnston, R C Coombes, R Coope, J J Gomm, C Zammit |
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| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Adult
medicine.medical_specialty Cancer Research Fibroblast Growth Factor 8 Colon medicine.medical_treatment Mammary gland Breast Neoplasms lactation Biology Fibroblast growth factor Breast cancer Internal medicine Progesterone receptor medicine Biomarkers Tumor Humans skin and connective tissue diseases Fallopian Tubes Aged human breast cancer Aged 80 and over Milk Human Growth factor Uterus Molecular and Cellular Pathology Cancer Epithelial Cells Ductal carcinoma Middle Aged medicine.disease Immunohistochemistry Fibroblast Growth Factors Gene Expression Regulation Neoplastic medicine.anatomical_structure Endocrinology Oncology Cancer research Female Cell Division |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Fibroblast growth factor 8 can transform NIH3T3 cells and its expression has been found to be associated with breast and prostate cancer. Following our finding that fibroblast growth factor 8 mRNA expression is increased in breast cancer, we have undertaken an immunohistochemistry study of fibroblast growth factor 8 expression in a series of human breast tissues and other normal tissues. Our findings confirm increased expression of fibroblast growth factor 8 in malignant breast tissue but also show significant fibroblast growth factor 8 expression in non-malignant breast epithelial cells. No significant difference in fibroblast growth factor 8 expression was found between different grades of ductal carcinoma, lobular carcinoma and ductal carcinoma in-situ or cancer of different oestrogen receptor, progesterone receptor or nodal status. The highest levels of fibroblast growth factor 8 expression were found in lactating breast tissues and fibroblast growth factor 8 was also detected in human milk. A survey of other normal tissues showed that fibroblast growth factor 8 is expressed in the proliferative cells of the dermis and epithelial cells in colon, ovary fallopian tube and uterus. Fibroblast growth factor 8 appears to be expressed in several organs in man and appears to have an importance in lactation. British Journal of Cancer (2002) 86, 1097–1103. DOI: 10.1038/sj/bjc/6600213 www.bjcancer.com © 2002 Cancer Research UK |
| Databáze: | OpenAIRE |
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