The enigmatic sperm proteins in mammalian fertilization: an overview†
Autor: | Neha Rajput, Gagandeep Kaur Gahlay |
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Rok vydání: | 2020 |
Předmět: |
Male
0301 basic medicine endocrine system Reproductive technology Biology 03 medical and health sciences Human fertilization medicine Animals Zona pellucida Receptor Mammals Sperm-Ovum Interactions 030102 biochemistry & molecular biology urogenital system Cell Biology General Medicine Spermatozoa Cell surface molecules Sperm Cell biology 030104 developmental biology Membrane medicine.anatomical_structure Reproductive Medicine Fertilization Oviduct |
Zdroj: | Biology of Reproduction. 103:1171-1185 |
ISSN: | 1529-7268 0006-3363 |
Popis: | Mammalian fertilization involves a physical interaction between a sperm and an egg followed by molecular interactions amongst their various cell surface molecules. These interactions are initially mediated on the egg’s outermost matrix, zona pellucida (ZP), and then its plasma membrane. To better understand this process, it is pertinent to find the corresponding molecules on sperm that interact with ZP or the egg’s plasma membrane. Although currently, we have some knowledge about the binding partners for egg’s plasma membrane on sperm, yet the ones involved in an interaction with ZP have remained remarkably elusive. This review provides comprehensive knowledge about the various sperm proteins participating in mammalian fertilization and discusses the possible reasons for not being able to identify the strong sperm surface candidate (s) for ZP adhesion. It also hypothesizes the existence of a multi-protein complex(s), members of which participate in oviduct transport, cumulus penetration, zona adhesion, and adhesion/fusion with the egg’s plasma membrane; with some protein(s) having multiple roles during this process. Identification of these proteins is crucial as it improves our understanding of the process and allows us to successfully treat infertility, develop contraceptives, and improve artificial reproductive technologies. |
Databáze: | OpenAIRE |
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