Association of genes coding for the α-4, α-5, β-2 and β-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence
| Autor: | Elisabeth Neidhart, Alain Malafosse, Claudette Duret, Nader Perroud, Jean-François Etter, Daniel Bertrand, Catherine Buresi, Jean-Charles Hoda, Marcus R. Munafò |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Nicotine dependence Beta-3 adrenergic receptor medicine.medical_specialty Genotype Medicine (miscellaneous) Alpha (ethology) Nerve Tissue Proteins Receptors Nicotinic Toxicology Polymerase Chain Reaction Polymorphism Single Nucleotide chemistry.chemical_compound Cigarette smoking Internal medicine Genetics medicine Humans Genetic Predisposition to Disease ddc:576.5 Cotinine Saliva ddc:613 biology CHRNA5 Smoking Novelty seeking Tobacco Use Disorder Middle Aged ddc:616.8 Psychiatry and Mental health Clinical Psychology Nicotinic acetylcholine receptor Nicotinic agonist Endocrinology chemistry Nicotinic receptors Anesthesia biology.protein Female Psychology Polymorphism Restriction Fragment Length |
| Zdroj: | Addictive Behaviors, Vol. 34, No 9 (2009) pp. 772-5 |
| ISSN: | 0306-4603 |
| DOI: | 10.1016/j.addbeh.2009.05.010 |
| Popis: | We assessed whether smoking behavior was associated with nine polymorphisms in genes coding for the nicotinic receptor subunits alpha-4 (rs1044394, rs1044396, rs2236196 and rs2273504), alpha-5 (rs16969968), beta-2 (rs2072661 and rs4845378) and beta-3 (rs4953 and rs6474413).We conducted an Internet survey and collected saliva by mail for DNA and cotinine analyses, in Switzerland in 2003. We conducted DNA analyses for 277 participants and cotinine analyses for 141 current daily smokers. Cotinine levels were higher in carriers of the CC genotype of CHRNA4 rs1044396 (371 ng/ml) than in those with the CT or TT genotypes (275 ng/ml, p=0.049), a difference of 0.53 standard deviation units. However, this difference was not robust to correction for multiple testing using Bonferroni adjustment. These 9 polymorphisms were not otherwise associated with smoking behavior and nicotine dependence. There were possible associations between the temperament trait novelty seeking and CHRNA4 rs1044396, CHRNA5 rs16969968 and CHRNB2 rs4845378, but these associations were not robust to correction for multiple testing. We conclude that the analysis of polymorphisms in genes coding for four nicotinic acetylcholine receptor subunits (CHRNA4, CHRNA5, CHRNB2 and CHRNB3) and several smoking-related phenotypes revealed no statistically significant association. |
| Databáze: | OpenAIRE |
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