Development and validation of a clinicopathological‐based nomogram to predict seeding risk after percutaneous thermal ablation of primary liver carcinoma

Autor: Jiayan Ni, Yiquan Jiang, Jinhua Huang, Zhimei Huang, Mengxuan Zuo, Tianqi Zhang, Chao An
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Cancer Research
Multivariate statistics
Percutaneous
Time Factors
Cholangiocarcinoma
0302 clinical medicine
Risk Factors
Medicine
Original Research
Aged
80 and over
Liver Neoplasms
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Treatment Outcome
Oncology
030220 oncology & carcinogenesis
primary liver carcinoma
Seeding
Female
seeding
Adult
medicine.medical_specialty
China
Carcinoma
Hepatocellular
risk analysis
Thermal ablation
Urology
Risk Assessment
lcsh:RC254-282
Decision Support Techniques
nomogram
03 medical and health sciences
Young Adult
thermal ablation
Neoplasm Seeding
Predictive Value of Tests
Humans
Radiology
Nuclear Medicine and imaging
Aged
Retrospective Studies
Radiofrequency Ablation
Receiver operating characteristic
business.industry
Proportional hazards model
Reproducibility of Results
Clinical Cancer Research
Nomogram
Confidence interval
Nomograms
030104 developmental biology
Bile Duct Neoplasms
business
Zdroj: Cancer Medicine, Vol 9, Iss 18, Pp 6497-6506 (2020)
Cancer Medicine
ISSN: 2045-7634
Popis: Objectives To develop a clinicopathological‐based nomogram to improve the prediction of the seeding risk of after percutaneous thermal ablation (PTA) in primary liver carcinoma (PLC). Methods A total of 2030 patients with PLC who underwent PTA were included between April 2009 and December 2018. The patients were grouped into a training dataset (n = 1024) and an external validation dataset (n = 1006). Baseline characteristics were collected to identify the risk factors of seeding after PTA. The multivariate Cox proportional hazards model based on the risk factors was used to develop the nomogram, which was used for assessment for its predictive accuracy using mainly the Harrell's C‐index and receiver operating characteristic curve (AUC). Results The median follow‐up time was 30.3 months (range, 3.2‐115.7 months). The seeding risk was 0.89% per tumor and 1.5% per patient in the training set. The nomogram was developed based on tumor size, subcapsular, α‐fetoprotein (AFP), and international normalized ratio (INR). The 1‐, 2‐, and 3‐year cumulative seeding rates were 0.1%, 0.7% and 1.2% in the low‐risk group, and 1.7%, 6.3% and 6.3% in the high‐risk group, respectively, showing significant statistical difference (P
Seeding on the thoracoabdominal wall from primary liver carcinoma is a potential complication after percutaneous thermal ablation. Seeding risk is a liver ablation complication that affects future oncology management. A calibrated and objective model to predict seeding risk after liver ablation may guide patient selection and ablation treatment.
Databáze: OpenAIRE
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