Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns
| Autor: | Øivind Midttun, Per Magne Ueland, Wenche Nystad, Michael C. Wu, Bettina Kulle Andreassen, Herman T. den Dekker, Emma L. Beckett, Albert Hofman, Bonnie R. Joubert, Eric A.P. Steegers, Shyamal D. Peddada, Jon Bohlin, Sarah E. Reese, André G. Uitterlinden, Oscar H. Franco, Roy Miodini Nilsen, Tianyuan Wang, Vincent W. V. Jaddoe, Stein Emil Vollset, Abbas Dehghan, Siri E. Håberg, Janine F. Felix, Marjolein J. Peters, Johan C. de Jongste, Stephanie J. London, Joyce B. J. van Meurs, Henning Tiemeier, Symen Ligthart, Liesbeth Duijts |
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| Přispěvatelé: | Epidemiology, Erasmus MC other, Pediatrics, Pediatric Surgery, Psychiatry, Internal Medicine, Obstetrics & Gynecology |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Monocarboxylic Acid Transporters Offspring Science LIM-Homeodomain Proteins Peripherins General Physics and Astronomy Disease Biology Bioinformatics GPI-Linked Proteins General Biochemistry Genetics and Molecular Biology Article Epigenesis Genetic 03 medical and health sciences Folic Acid Pregnancy medicine Humans Epigenetics Genetics Fetus Multidisciplinary Serine Endopeptidases Neural tube Infant Newborn Gene Expression Regulation Developmental General Chemistry Epigenome DNA Methylation medicine.disease 3. Good health Cytoskeletal Proteins 030104 developmental biology medicine.anatomical_structure embryonic structures DNA methylation Female Kallikreins Cell Adhesion Molecules Transcription Factors |
| Zdroj: | Nature Communications, 7. Nature Publishing Group Nature Communications Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016) |
| ISSN: | 2041-1723 |
| Popis: | Folate is vital for fetal development. Periconceptional folic acid supplementation and food fortification are recommended to prevent neural tube defects. Mechanisms whereby periconceptional folate influences normal development and disease are poorly understood: epigenetics may be involved. We examine the association between maternal plasma folate during pregnancy and epigenome-wide DNA methylation using Illumina's HumanMethyl450 Beadchip in 1,988 newborns from two European cohorts. Here we report the combined covariate-adjusted results using meta-analysis and employ pathway and gene expression analyses. Four-hundred forty-three CpGs (320 genes) are significantly associated with maternal plasma folate levels during pregnancy (false discovery rate 5%); 48 are significant after Bonferroni correction. Most genes are not known for folate biology, including APC2, GRM8, SLC16A12, OPCML, PRPH, LHX1, KLK4 and PRSS21. Some relate to birth defects other than neural tube defects, neurological functions or varied aspects of embryonic development. These findings may inform how maternal folate impacts the developing epigenome and health outcomes in offspring. Folic acid is routinely recommended for women trying to conceive to ensure proper fetal development. Here, the authors perform a large epigenomics study to examine which fetal epigenetic changes are associated with varied maternal plasma folate levels. |
| Databáze: | OpenAIRE |
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