A 28 Day Clinical Assessment of a Lactic Acid-containing Antimicrobial Intimate Gel Wash Formulation on Skin Tolerance and Impact on the Vulvar Microbiome
| Autor: | Ying Chen, Karen McCue, Alan D. G. Brown, Jeremy E. Wilkinson, Joseph R. Rubino, Elizabeth Bruning |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) feminine gel wash vulvar skin pH 030106 microbiology vulvovaginal environment Biochemistry Microbiology bacterial 16S rRNA gene Article Vulva 03 medical and health sciences chemistry.chemical_compound Cleanser fungal ITS Medicine feminine hygiene Pharmacology (medical) Microbiome Food science General Pharmacology Toxicology and Pharmaceutics vulvar microbiome integumentary system business.industry lcsh:RM1-950 skin microflora lactic acid Antimicrobial Lactic acid FEMININE HYGIENE lcsh:Therapeutics. Pharmacology 030104 developmental biology Infectious Diseases medicine.anatomical_structure chemistry Diversity analysis Itching medicine.symptom business |
| Zdroj: | Antibiotics Volume 9 Issue 2 Antibiotics, Vol 9, Iss 2, p 55 (2020) |
| ISSN: | 2079-6382 |
| DOI: | 10.3390/antibiotics9020055 |
| Popis: | While intimate feminine hygiene products are widely used as part of daily cleansing routines, little is known about how these products impact the vulvovaginal area and its microbiome stability. This 4 week clinical study assessed tolerance of a novel gel wash containing lactic acid (pH 4.2) for external daily use when used on the external genital area and its effects on skin moisturization, vulvar skin pH, and the vulvar microbiome. After a 7 day pre-study conditioning period, 36 healthy females in three balanced age groups (18&ndash 29, 30&ndash 44, and 45&ndash 55 years) used the gel wash to cleanse their external genital area (mons pubis and vulva) and entire body at least once per day for 28 days. Skin tolerance of the gel wash was assessed by the gynecologist. Effects of the gel wash on vulvar skin microbiota were studied by performing bacterial 16S rRNA and fungal internal transcribed spacer (ITS) microbial richness and diversity analysis. Based on gynecologic assessment after 28 days of use, the gel wash showed acceptable tolerance, with no signs of increased dryness, redness, edema, itching, stinging, or burning. Use of the gel wash was associated with a significant increase in both short-term (single application) and longer-term (daily use for 28 days) skin moisturization. There was no significant change in vulvar skin pH over time with daily product use, and the gel wash did not significantly affect the natural vulvar microbiome species richness or diversity for bacteria or fungi. Results showed that this gel wash is a mild, moisturizing cleanser that maintains the natural pH and microbial diversity of vulvar skin. To our knowledge, this was the first study to assess the effect of an antimicrobial feminine gel wash on the natural pH and vulvar microbiome habitat of the skin using bacterial 16S rRNA and fungal ITS genetic sequencing techniques. |
| Databáze: | OpenAIRE |
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