Hepatotoxicity after treatment with sulfasalazine
| Autor: | Joe D. Haines |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Male medicine.medical_specialty Abdominal pain Fulminant 030209 endocrinology & metabolism Disease 030204 cardiovascular system & hematology Gastroenterology Drug Hypersensitivity Necrosis 03 medical and health sciences 0302 clinical medicine Crohn Disease Liver Function Tests Sulfasalazine Internal medicine medicine Humans Right lower quadrant Liver damage business.industry Liver Diseases General Medicine Hypersensitivity reaction Liver Drug Eruptions Chemical and Drug Induced Liver Injury medicine.symptom business After treatment medicine.drug |
| Zdroj: | Postgraduate Medicine. 79:193-198 |
| ISSN: | 1941-9260 0032-5481 |
| DOI: | 10.1080/00325481.1986.11699392 |
| Popis: | A 42-year-old man with fever, right lower quadrant abdominal pain, and occasional rectal bleeding was diagnosed as having Crohn's disease. He was started on sulfasalazine (Azulfidine) therapy, and a generalized rash subsequently developed. When laboratory data indicated possible sulfasalazine hepatotoxicity, use of the drug was discontinued. Symptoms continued to worsen, however, and the patient died of fulminant hepatic necrosis. Comparison with similar cases showed that a hypersensitivity reaction was probably responsible for the liver damage, with a latent period that made recognition difficult. Thus, while fulminant hepatic necrosis is rare, this possibility must always be considered by the clinician when prescribing and monitoring therapy with sulfasalazine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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