A General Strategy to Install Amidine Functional Groups Along the Peptide Backbone

Autor:	Emily A. O’Brien, Krishna K. Sharma, Jacob Byerly-Duke, Luis A. Camacho, Brett VanVeller
Rok vydání:	2022
Předmět:	Colloid and Surface Chemistry General Chemistry Biochemistry Article Catalysis
Zdroj:	J Am Chem Soc
ISSN:	1520-5126 0002-7863
DOI:	10.1021/jacs.2c09085
Popis:	Amidines are a structural surrogate for peptide bonds, yet have received considerably little attention in peptides due to limitations in existing methods to access them. The synthetic strategy developed in this study represents the first robust and general procedure for the introduction of amidines into the peptide backbone. We exploit and further develop the utility and efficiency of thioimidate protecting groups as a means to side-step reactivity that ultimately renders existing methods unsuitable for the installation of amidines along the main-chain of peptides. This work is significant because it describes a generally applicable path to access unexplored peptide designs and architectures for new therapeutics made possible by the unique properties of amidines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa3482215c103c621cdc69c23c3840b https://doi.org/10.1021/jacs.2c09085 Zobrazit plný text záznamu