Linking Heterochromatin Protein 1 (HP1) to cancer progression
| Autor: | George Dialynas, Michael W. Vitalini, Lori L. Wallrath |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Euchromatin
Heterochromatin Chromosomal Proteins Non-Histone Health Toxicology and Mutagenesis Centromere Biology Article Non-histone protein Neoplasms Genetics Animals Humans Molecular Biology Regulation of gene expression Models Genetic Telomere Chromatin Histone Gene Expression Regulation Chromobox Protein Homolog 5 Histone methyltransferase Viruses biology.protein Disease Progression Heterochromatin protein 1 |
| Popis: | All cells of a given organism contain nearly identical genetic information, yet tissues display unique gene expression profiles. This specificity is in part due to transcriptional control by epigenetic mechanisms that involve post-translational modifications of histones. These modifications affect the folding of the chromatin fiber and serve as binding sites for non-histone chromosomal proteins. Here we discuss functions of the Heterochromatin Protein 1 (HP1) family of proteins that recognize H3K9me, an epigenetic mark generated by the histone methyltransferases SU(VAR)3-9 and orthologues. Loss of HP1 proteins causes chromosome segregation defects and lethality in some organisms; a reduction in levels of HP1 family members is associated with cancer progression in humans. These consequences are likely due to the role of HP1 in centromere stability, telomere capping and the regulation of euchromatic and heterochromatic gene expression. |
| Databáze: | OpenAIRE |
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