Amplified C lambda and c-abl genes are on the same marker chromosome in K562 leukemia cells
| Autor: | Beverly S. Emanuel, Peter C. Nowell, Jan Erikson, J R Selden, Eileen Wang, Antonio Palumbo, Carlo M. Croce, Giovanni Rovera, Linda A. Cannizzaro |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1983 |
| Předmět: |
Marker chromosome
Biology Philadelphia chromosome Cell Line hemic and lymphatic diseases Chromosomes Human 21-22 and Y medicine Humans Metaphase Genetics Multidisciplinary ABL Gene Amplification Nucleic Acid Hybridization Karyotype Oncogenes medicine.disease Molecular biology Chromosome Banding Leukemia Lymphoid Karyotyping Chromosome 21 Chromosome 22 Research Article K562 cells Chronic myelogenous leukemia |
| Popis: | The human leukemia cell line K562, derived from a patient with Philadelphia chromosome-positive chronic myelogenous leukemia, contains amplified c-abl oncogenes and unrearranged C lambda genes. Using in situ hybridization techniques, we have determined that the amplified c-abl and C lambda DNA sequences of K562 cells are both located on the same abnormal acrocentric marker chromosome, which may represent an altered Philadelphia chromosome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|