Effect of vaginal suppository on bacterial vaginitis based on Persian medicine (Iranian traditional medicine): a randomised double blind clinical study
| Autor: | Soodabeh Bioos, Majid Anushiravani, Somaye Mahroozade, Mohsen Amin, Nasrin Baery, Azizeh Ghasemi Nejad, Jale Aliasl, Roshanak Mokaberinejad, Malihe Karimi Darmiyan, Gholamreza Amin |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
medicine.medical_specialty Tribulus terrestris Iranian traditional medicine 01 natural sciences Double blind 03 medical and health sciences 0302 clinical medicine Double-Blind Method Internal medicine Metronidazole Tamarindus Tribulus Medicine Humans Persian business.industry Suppositories Obstetrics and Gynecology Vaginosis Bacterial Middle Aged medicine.disease humanities language.human_language Myrtus 0104 chemical sciences Anti-Bacterial Agents 010404 medicinal & biomolecular chemistry Foeniculum 030220 oncology & carcinogenesis Vaginal Suppository language Female Medicine Traditional Plant Preparations Bacterial vaginosis business Bacterial vaginitis medicine.drug Phytotherapy |
| Zdroj: | Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 38(8) |
| ISSN: | 1364-6893 |
| Popis: | This trial was conducted on 127 women aged 18-50 years with bacterial vaginosis to compare the vaginal suppository of metronidazole with Forzejeh, a vaginal suppository of herbal Persian medicine combination of Tribulus terrestris, Myrtus commuis, Foeniculum vulgare and Tamarindus indica. The patients (63 in metronidazole group and 64 in Forzejeh group) received the medications for 1 week. Their symptoms including the amount and odour of discharge and cervical pain were assessed using a questionnaire. Cervical inflammation and Amsel criteria (pH of vaginal discharge, whiff test, presence of clue cells and Gram staining) were investigated at the beginning of the study and 14 days after treatment. The amount and odour of discharge, Amsel criteria, pelvic pain and cervical inflammation significantly decreased in Forzejeh and metronidazole groups (p = .001). There was no statistically significant difference between the metronidazole and Fozejeh groups with respect to any of the clinical symptoms or the laboratory assessments. This study showed that Forzejeh, which is an herbal Persian medicine preparation, has a therapeutic effect the same as metronidazole in bacterial vaginosis. Impact statement What is already known on this subject? Bacterial vaginosis (BV) is a common problem in women. Common antibiotics for the treatment of BV include: metronidazole, tinidazole and clindamycin. Unfortunately, treatments often occur with a recurrence and failure. Therefore, alternative treatments are necessary. Many natural treatments are recommended for this condition in Persian Traditional Medicine sources. One of them is the vaginal suppository "Forzejeh" which is the combination of Tribulus terrestris, Myrtus commuis, Foeniculum vulgare and Tamarindus indica. These plants have antimicrobial activities. Forzejeh has been used for the treatment of BV in folk medicine for many years and has been formulated and standardised recently. What do the results of this study add? This study showed that the therapeutic effect of Forzejeh on bacterial vaginosis is similar to metronidazole. What are the implications of these findings for clinical practice and/or further research? A clinical study with a longer follow-up time is suggested for assessing the recurrence of BV after treatment with Forzejeh metronidazole. |
| Databáze: | OpenAIRE |
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