Pasteurella haemolytica A1 purified capsular polysaccharide does not stimulate interleukin-1 and tumor necrosis factor release by bovine monocytes and alveolar macrophages
| Autor: | Elisabeth J. Noel, C. Adlam, Charles J. Czuprynski |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Lipopolysaccharides
Lipopolysaccharide medicine.drug_class Polymyxin Immunology Biology complex mixtures Monocytes Microbiology chemistry.chemical_compound stomatognathic system medicine Animals Macrophage Secretion Polymyxin B General Veterinary Tumor Necrosis Factor-alpha Macrophages Monocyte Polysaccharides Bacterial Interleukin In vitro carbohydrates (lipids) stomatognathic diseases medicine.anatomical_structure chemistry Cattle Pasteurella Tumor necrosis factor alpha Bronchoalveolar Lavage Fluid Interleukin-1 |
| Zdroj: | Veterinary Immunology and Immunopathology. 28:157-163 |
| ISSN: | 0165-2427 |
| Popis: | Purified capsular polysaccharide (CPS) stimulated significant release of interleukin-1 (IL-1) activity from bovine blood monocytes but not alveolar macrophages in vitro. The ability of CPS to induce IL-1 release was resistant to boiling and inhibited by the addition of polymyxin beta. Thus, it is likely that the IL-1 release stimulated by CPS resulted from the small amount of contaminating lipopolysaccharide (LPS) that was present (an estimated 5 pg LPS per microgram CPS) rather than to a direct effect of CPS. Tumor necrosis factor activity was not detected in the culture supernatants of bovine monocytes incubated with purified CPS for 1-18 h in vitro. |
| Databáze: | OpenAIRE |
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