Retinal-detachment repair and vitreous-like-body reformation via a thermogelling polymer endotamponade
| Autor: | Graham E. Holder, Mein Jin Tan, Veluchamy A Barathi, Subramanian Krishnakumar, Sing Shy Liow, Rajamani Lakshminarayanan, Jayantha Gunaratne, Xinyi Su, Walter Hunziker, Asfa Alli-Shaik, Paul Zhao, Xian Jun Loh, Caroline Chee, Siew Li Lai, Clement Tan, Zengping Liu, Gopal Lingam, Bhav Harshad Parikh, Zibiao Li |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Intraocular pressure medicine.medical_specialty genetic structures Biocompatibility Polymers medicine.medical_treatment education Biomedical Engineering Medicine (miscellaneous) Cataract formation Bioengineering Vitrectomy Endotamponade Vitreoretinal Surgery Retina Tonometry Ocular 03 medical and health sciences 0302 clinical medicine Ophthalmology medicine Animals Humans Pain Management Surface Tension Intraocular Pressure Chemistry Retinal Detachment Retinal detachment repair Vitreoretinal surgery eye diseases Computer Science Applications Vitreous Body Macaca fascicularis 030104 developmental biology Models Animal Rabbits sense organs Tamponade Gels 030217 neurology & neurosurgery Biotechnology |
| Zdroj: | Nature Biomedical Engineering. 3:598-610 |
| ISSN: | 2157-846X |
| Popis: | Internal-tamponade agents are crucial surgical adjuncts in vitreoretinal surgery. Clinically used endotamponade agents act through buoyancy forces, yet can result in prolonged post-operative positioning, temporary loss of vision, raised intra-ocular pressure, cataract formation or the need for additional removal surgery. Here, we describe a thermogelling polymer that provides an internal tamponade effect through surface tension and swelling counter-forces. We tested the long-term biocompatibility of the polymer endotamponade in rabbit vitrectomy models, and its surgical efficacy and biocompatibility in a non-human primate retinal-detachment model. We also show that, while the thermogel biodegrades during the three months following surgery, it promotes the reformation of a vitreous-like body that mimics the biophysical properties of the natural vitreous. The thermogelling endotamponade might serve as a long-term vitreous substitute. A thermogelling polymer that acts as an internal tamponade can repair detached retinas and trigger the formation of a vitreous-like body, as shown in retinal-detachment rabbit and non-human-primate models. |
| Databáze: | OpenAIRE |
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