Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study
| Autor: | Julio Velasco, Luis Estuardo Lombardi, Magdalena Grce, Hai Rim Shin, Andrzej Nowakowski, Ana Félix, Miguel Andújar, Luciano Mariani, Marcus Aurelho Lima, Silvia de Sanjosé, Omar Clavero, F. Xavier Bosch, Christine Clavel, Elena Kasamatsu, Ermina Iljazovic, Chris J. L. M. Meijer, Thomas C. Wright, Aekunbiola Banjo, Theodoros Agorastos, Victoria Garcia-Barriola, Maria Alejo, Michael Odida, Enrique Lerma, Ashrafun Nessa, Asha Jain, Waleed Al-Jassar, Doudja Hammouda, Efren J. Domingo, Luis Eduardo Bravo, Wim Quint, Gustavo Adolfo Hernandez Suarez, Núria Guimerà, Maria Tzardi, Adela Pelayo, Annabelle Ferrera, Alp Usubutun, Patricia Alonso de Ruiz, Gloria I. Sanchez, Xavier Castellsagué, Clara Menendez, D.T. Geraets, Belen Lloveras, Esther Oliva, Ivo Šteiner, Jaume Ordi, Silvio Tatti, Jo Ellen Klaustermeier, Rodrigo Prado, Suzanne M. Garland, Saibua Chichareon, Nubia Muñoz, Toshiyuki Sasagawa, Sara Tous, Muhieddine Seoud, Ana Puras, Cecilia L. Llave, Chou Cheng-Yang, Laia Alemany, Eugenia Cruz, Antonio Llombart-Bosch, You-Lin Qiao, Jacob Bornstein, Carlos S. Vallejos |
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| Přispěvatelé: | Pathology, CCA - Oncogenesis |
| Rok vydání: | 2010 |
| Předmět: |
Oncology
International Cooperation Uterine Cervical Neoplasms Polymerase Chain Reaction Human papillomaviruses cervical cancer 0302 clinical medicine Genotype Mass Screening Young adult 10. No inequality Papillomaviridae Cervical cancer Aged 80 and over 0303 health sciences Paraffin Embedding medicine.diagnostic_test Age Factors Middle Aged 3. Good health 030220 oncology & carcinogenesis Carcinoma Squamous Cell Female Adult medicine.medical_specialty Adolescent HPV vaccines Adenocarcinoma 03 medical and health sciences Carcinoma Adenosquamous Young Adult Internal medicine medicine Humans Neoplasm Invasiveness Genetic Testing Papillomavirus Vaccines Genotyping 030304 developmental biology Genetic testing Aged Retrospective Studies Gynecology business.industry Papillomavirus Infections Basic Medical Sciences medicine.disease Cross-Sectional Studies Logistic Models BIOMEDICINE AND HEALTHCARE DNA Viral Linear Array HPV Genotyping Test Linear Models Cervarix business |
| Zdroj: | de Sanjose, S, Quint, W G V, Alemany, L, Geraets, D T, Klaustermeier, J E, Lloveras, B, Tous, S, Felix, A, Bravo, L E, Shin, HR, Vallejos, C S, de Ruiz, P A, Lima, M A, Guimera, N, Clavero, O, Alejo, M, Llombart-Bosch, A, Cheng-Yang, C, Tatti, S A, Kasamatsu, E, Iljazovic, E, Odida, M, Prado, R, Seoud, M, Grce, M, Usubutun, A, Jain, A, Suarez, G A H, Lombardi, L E, Banjo, A, Menendez, C, Domingo, E J, Velasco, J, Nessa, A, Chichareon, S C B, Qiao, Y L, Lerma, E, Garland, S M, Sasagawa, T, Ferrera, A, Hammouda, D, Mariani, L, Pelayo, A, Steiner, I, Oliva, E, Meijer, C J L M, Al-Jassar, W F, Cruz, E, Wright, T C, Puras, A, Llave, C L, Tzardi, M, Agorastos, T, Garcia-Barriola, V, Clavel, C, Ordi, J, Andujar, M, Castellsague, X, Sanchez, G I, Nowakowski, A M, Bornstein, J, Munoz, N & Bosch, F X 2010, ' Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study ', Lancet Oncology, vol. 11, no. 11, pp. 1048-1056 . https://doi.org/10.1016/S1470-2045(10)70230-8 Lancet Oncology, 11(11), 1048-1056. Lancet Publishing Group Lancet Oncology |
| ISSN: | 1474-5488 1470-2045 |
| Popis: | Summary Background Knowledge about the distribution of human papillomavirus (HPV) genotypes in invasive cervical cancer is crucial to guide the introduction of prophylactic vaccines. We aimed to provide novel and comprehensive data about the worldwide genotype distribution in patients with invasive cervical cancer. Methods Paraffin-embedded samples of histologically confirmed cases of invasive cervical cancer were collected from 38 countries in Europe, North America, central South America, Africa, Asia, and Oceania. Inclusion criteria were a pathological confirmation of a primary invasive cervical cancer of epithelial origin in the tissue sample selected for analysis of HPV DNA, and information about the year of diagnosis. HPV detection was done by use of PCR with SPF-10 broad-spectrum primers followed by DNA enzyme immunoassay and genotyping with a reverse hybridisation line probe assay. Sequence analysis was done to characterise HPV-positive samples with unknown HPV types. Data analyses included algorithms of multiple infections to estimate type-specific relative contributions. Findings 22 661 paraffin-embedded samples were obtained from 14 249 women. 10 575 cases of invasive cervical cancer were included in the study, and 8977 (85%) of these were positive for HPV DNA. The most common HPV types were 16, 18, 31, 33, 35, 45, 52, and 58 with a combined worldwide relative contribution of 8196 of 8977 (91%, 95% CI 90–92). HPV types 16 and 18 were detected in 6357 of 8977 of cases (71%, 70–72) of invasive cervical cancer. HPV types 16, 18, and 45 were detected in 443 of 470 cases (94%, 92–96) of cervical adenocarcinomas. Unknown HPV types that were identified with sequence analysis were 26, 30, 61, 67, 69, 82, and 91 in 103 (1%) of 8977 cases of invasive cervical cancer. Women with invasive cervical cancers related to HPV types 16, 18, or 45 presented at a younger mean age than did those with other HPV types (50·0 years [49·6–50·4], 48·2 years [47·3–49·2], 46·8 years [46·6–48·1], and 55·5 years [54·9–56·1], respectively). Interpretation To our knowledge, this study is the largest assessment of HPV genotypes to date. HPV types 16, 18, 31, 33, 35, 45, 52, and 58 should be given priority when the cross-protective effects of current vaccines are assessed, and for formulation of recommendations for the use of second-generation polyvalent HPV vaccines. Our results also suggest that type-specific high-risk HPV-DNA-based screening tests and protocols should focus on HPV types 16, 18, and 45. Funding Spanish grants from Instituto de Salud Carlos III, Agencia de Gestio d'Ajuts Universitaris i de Recerca, Marato de TV3 Foundation, and unrestricted grants from GlaxoSmithKline Biologicals, Sanofi Pasteur MSD, and Merck. |
| Databáze: | OpenAIRE |
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