Age-dependent interactive changes in serotonergic and noradrenergic cortical axon terminals in F344 rats
| Autor: | Sadamu Nakai, Tetsuya Shirokawa, Ken-ichi Isobe, Wataru Matsunaga |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Aging Benzylamines Serotonin Presynaptic Terminals Serotonergic Norepinephrine Dorsal raphe nucleus medicine Animals Neurotransmitter Uptake Inhibitors Axon Maprotiline Neuronal Plasticity Adrenergic Uptake Inhibitors Chemistry General Neuroscience General Medicine Immunohistochemistry Rats Inbred F344 Frontal Lobe Rats Electrophysiology medicine.anatomical_structure Monoamine neurotransmitter nervous system Locus coeruleus Neuroscience Sprouting medicine.drug |
| Zdroj: | Neuroscience Research. 54:220-229 |
| ISSN: | 0168-0102 |
| Popis: | In the frontal cortex of aging rats, we found an increase in sprouting of the noradrenergic (NA) axons originated from the locus coeruleus (LC). The serotonergic (5-HT) axons originating from the dorsal raphe (DR) share the same cortical area and their age-dependent changes and interactions with NA axons were still unclear. To compare quantitatively the extent of axonal sprouting of DR and LC neurons in the frontal cortex, we extracellularly recorded from both DR and LC neurons in the same animals and antidromically stimulated 32 cortical sites (a pair of stimulating electrodes was moved at 100-mum intervals from 500 to 2000 microm in depth). In addition, to examine the effects of degeneration of 5-HT axons on NA axons, and vice versa, we used specific neurotoxins for 5-HT (PCA) or NA (DSP-4) axons. We also used noradrenaline uptake inhibitor (maprotiline) to verify the effects of NA on degeneration of 5-HT axons. Results suggested that 5-HT axons sprouted between 15 and 17 months of age and noradrenaline accelerated the age-dependent change of 5-HT axons. |
| Databáze: | OpenAIRE |
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