Novel Thogotovirus Associated with Febrile Illness and Death, United States, 2014
| Autor: | Daniel M. Pastula, D. Charles Hunt, Amy J. Lambert, Cynthia S. Goldsmith, Olga I. Kosoy, Dana J. Hawkinson, J. Erin Staples |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Microbiology (medical) Fever febrile illness Epidemiology viruses Expedited lcsh:Medicine Autopsy Genome Viral Tick Virus Serology lcsh:Infectious and parasitic diseases Novel Thogotovirus Species Associated with Febrile Illness and Death United States 2014 Fatal Outcome death Influenza Human neutralization tests Humans Medicine lcsh:RC109-216 high-throughput nucleotide sequencing Phylogeny Leukopenia biology business.industry Research lcsh:R Kansas Middle Aged Heartland virus biology.organism_classification medicine.disease Virology United States Bourbon virus Infectious Diseases RNA Viral Thogotovirus medicine.symptom business |
| Zdroj: | Emerging Infectious Diseases, Vol 21, Iss 5, Pp 760-764 (2015) Emerging Infectious Diseases |
| ISSN: | 1080-6059 1080-6040 |
| Popis: | Bourbon virus is a newly discovered pathogen associated with human illness and death. A previously healthy man from eastern Kansas, USA, sought medical care in late spring because of a history of tick bite, fever, and fatigue. The patient had thrombocytopenia and leukopenia and was given doxycycline for a presumed tickborne illness. His condition did not improve. Multiorgan failure developed, and he died 11 days after illness onset from cardiopulmonary arrest. Molecular and serologic testing results for known tickborne pathogens were negative. However, testing of a specimen for antibodies against Heartland virus by using plaque reduction neutralization indicated the presence of another virus. Next-generation sequencing and phylogenetic analysis identified the virus as a novel member of the genus Thogotovirus. |
| Databáze: | OpenAIRE |
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