Optimized self-immolative near-infrared probe based on hemicyanine for highly specific monitoring thiophenols in living systems
| Autor: | Dan−Dan Feng, Suling Feng, Wei−Ning Liu, Guisheng Zhang, Yi−Pin Zhang, Yi−Jun Gong |
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| Rok vydání: | 2020 |
| Předmět: |
Detection limit
Fluorophore 010401 analytical chemistry Near-infrared spectroscopy 02 engineering and technology Carbocyanines 021001 nanoscience & nanotechnology Photochemistry 01 natural sciences 0104 chemical sciences Analytical Chemistry chemistry.chemical_compound chemistry Linear range Phenols Dinitrophenyl Sulfhydryl Compounds 0210 nano-technology Selectivity Fluorescent Dyes |
| Zdroj: | Talanta. 224 |
| ISSN: | 1873-3573 |
| Popis: | In this paper, utilizing the same recognition group dinitrophenyl and hydroxyl functional NIR fluorophore hemicyanine, directly-linked probe CyNO2 and self-immolative probe CyBNO2 were developed for evaluation of sensing PhSH. Though CyNO2 was easily synthesized and sensitive to mercapto, the probe CyBNO2 showed higher selectivity, broader linear range from 1.0 × 10−7 to 7.0 × 10−6 M with lower detection limit of 22 nM for PhSH. Moreover, CyBNO2 was successfully applied for monitoring PhSH in living cells and in vivo, indicating the great potential of self-immolative probes. |
| Databáze: | OpenAIRE |
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