Influence of Citalopram and Chlorimipramine on Uptake of 5-HT by Isolated Perfused Guinea Pig Lungs
| Autor: | B. Fjalland |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Serotonin Guinea Pigs In Vitro Techniques Pharmacology Citalopram Toxicology Guinea pig Dibenzazepines medicine Animals Lung 5-HT receptor Benzofurans Dose-Response Relationship Drug Propylamines Chemistry In vitro Concentration dependent medicine.anatomical_structure Clomipramine Female Serotonin Antagonists Perfusion medicine.drug |
| Zdroj: | Acta Pharmacologica et Toxicologica. 42:377-380 |
| ISSN: | 0001-6683 |
| DOI: | 10.1111/j.1600-0773.1978.tb02220.x |
| Popis: | A method is described for the preparation and perfusion in vitro of isolated guinea pig lungs, 5-HT is rapidly taken up from a perfusing solution by the organ (about 70% uptake). In the concentration range 10(-7) to 5 X 10(-6) M citalopram concentration dependently inhibited the uptake of 5-HT by the lung preparation. Chlorimipramine inhibited the uptake of 5-HT only by 40--50%, and the inhibition was not concentration dependent. The method used seems to be a reliable model for studying the uptake of 5-HT. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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