Lack of association between ENAM gene polymorphism and dental caries in primary and permanent teeth in Czech children
| Autor: | Petra Borilova Linhartova, Kristína Musilová, Martina Kukletová, Lenka Zackova, Lubomír Kukla, Tereza Deissová, Lydie Izakovičová Hollá |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Czech Adolescent Genotype Permanent dentition Dentistry Dental Caries Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Humans Medicine Tooth Deciduous Child General Dentistry Czech Republic Permanent teeth Extracellular Matrix Proteins DMF Index business.industry Infant 030206 dentistry language.human_language Dentition Permanent 030104 developmental biology Child Preschool language Female Gene polymorphism ENAM business |
| Zdroj: | Clinical Oral Investigations. 22:1873-1877 |
| ISSN: | 1436-3771 1432-6981 |
| Popis: | The enamelin gene (ENAM) polymorphism (rs12640848) was recently associated with dental caries in primary teeth in Polish children. The aims of the present study were to prove this association in primary dentition and to find a possible effect of this variant on caries development in permanent dentition in Czech children.This study comprised 905 Czech children. Totally, 187 children aged 2-6 years with primary dentition [78 healthy subjects (with decayed/missing/filled teeth, dmft = 0) and 109 patients with early childhood caries (ECC; dmft ≥ 1)] were included in this case-control study. In addition, 177 subjects aged 13-15 years without caries (DMFT = 0) and 541 children with dental caries (DMFT ≥ 1) in permanent dentition were selected from the ELSPAC study. Genotype determination of the ENAM polymorphism (rs12640848) was based on the TaqMan method.No significant differences in the allele or genotype frequencies between the caries-free children and those affected by dental caries were observed in both primary and permanent dentitions.Lack of association between the ENAM polymorphism (rs12640848) and dental caries in Czech children was detected.Although ENAM is considered as a candidate gene for dental caries, the presence of the ENAM variant (rs12640848) cannot be used as a risk factor of this multifactorial disease in the Czech population. |
| Databáze: | OpenAIRE |
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