Discovery of a novel class of potent HIV-1 protease inhibitors containing the (R)-(hydroxyethyl)urea isostere
| Autor: | John J. Talley, J J Marr, Daniel P. Getman, Heintz Robert M, Kathryn Houseman, Michael Clare, Decrescenzo Gary A, Richard A. Mueller, M L Bryant, K.L. Reed |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
chemistry.chemical_classification
biology Stereochemistry Isostere Stereoisomerism Biological activity HIV Protease Inhibitors Antiviral Agents Virus Structure-Activity Relationship Enzyme chemistry Biochemistry HIV-1 protease Enzyme inhibitor Drug Discovery biology.protein Humans Hydroxyurea Urea Molecular Medicine Structure–activity relationship |
| Zdroj: | Journal of Medicinal Chemistry. 36:288-291 |
| ISSN: | 1520-4804 0022-2623 |
| DOI: | 10.1021/jm00054a014 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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