| Autor: |
Bita Divsalar, Tahereh Kalantari, Soheila Mohebbi, Ardeshir Bahmanimehr, Amin Shahsavani, Afshin Borhani-Haghighi |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Laboratory medicine. |
| ISSN: |
1943-7730 |
| Popis: |
Objective The main concern about measuring the concentration of rivaroxaban by anti-Xa assay in some laboratories is the lack of a commercial specific calibrator in emergencies. Therefore, this study aimed at providing a homemade anti-Xa calibrator and commercial low molecular weight heparin (LMWH) anti-Xa calibrator. Methods The anti-Xa plasma concentration of rivaroxaban was measured in 70 patients using a commercial specific anti-Xa calibrator, a commercial LMWH anti-Xa calibrator, and a homemade anti-Xa calibrator. Results We demonstrated a significant correlation and agreement (P < .001) between LMWH-calibrated anti-Xa and the commercial specific calibrator. A significant correlation (P < .001) was found between homemade calibrated anti-Xa made by normal pooled plasma and that calibrated with a commercial specific drug. The nonspecific homemade and LMWH calibrators had excellent agreement (P < .001) and can be used interchangeably. Conclusion Our data showed that for estimating rivaroxaban concentrations, the LMWH calibrator could be used as an alternative calibrator in the anti-Xa assay. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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