Sex differences in the endocrine system in response to protein intake early in life
| Autor: | Ricardo, Closa-Monasterolo, Natàlia, Ferré, Verónica, Luque, Marta, Zaragoza-Jordana, Veit, Grote, Martina, Weber, Berthold, Koletzko, Piotr, Socha, Dariusz, Gruszfeld, Roman, Janas, Annick, Xhonneux, Elena, Dain, Silvia, Scaglioni, Joaquin, Escribano, Fiammetta, Vecchi |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Leptin
Male medicine.medical_specialty Medicine (miscellaneous) Nutritional Status High-protein diet Endocrine System Biology medicine.disease_cause Body Mass Index chemistry.chemical_compound Child Development Sex Factors Double-Blind Method Internal medicine medicine Endocrine system Humans Insulin-Like Growth Factor I Infant Nutritional Physiological Phenomena Creatinine Nutrition and Dietetics C-peptide Body Weight Infant Body Height Infant Formula Insulin-Like Growth Factor Binding Protein 2 Endocrinology chemistry Female Dietary Proteins Body mass index Sex characteristics Hormone |
| Zdroj: | The American journal of clinical nutrition. 94 |
| ISSN: | 1938-3207 |
| Popis: | Background: Nutritional factors during a sensitive period can influence child development in a sex-related manner. Objective: Our aim was to investigate whether sex modulates the responses of relevant biochemical parameters and growth to different protein intakes early in life. Design: In a randomized controlled trial, formula-fed infants were assigned to receive formula with higher protein (HP) or lower protein (LP) content. The main outcome measures were insulin-like growth factor (IGF)-1 axis parameters, weight, length, BMI, leptin, and C-peptide/creatinine ratio at 6 mo of age. Dietary intake during the first 6 mo of life was also assessed. Results: The IGF-1 axis response to HP feeding was modulated by sex. Total and free IGF-1 and IGF binding protein 3 concentrations were higher in girls than in boys. Compared with the LP diet, the HP diet was associated with higher IGF-1 and lower IGF binding protein 2 secretion. The response to this HP content formula tended to be stronger in girls than in boys. The HP diet was associated with a higher C-peptide/creatinine ratio. The leptin concentration was higher in girls than in boys and was correlated to the IGF-1 axis parameters. No interaction between sex and nutritional intervention was shown on growth. Conclusions: Our findings show that the endocrine response to a high protein diet early in life may be modulated by sex. The IGF-1 axis of female infants shows a stronger response to the nutritional intervention than does that of male infants, but there is no enhanced effect on growth. This trial was registered at clinicaltrials. gov as NCT00338689. © 2011 American Society for Nutrition. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|