l-Canaline: A potent antimetabolite and anti-cancer agent from leguminous plants
| Autor: | Gerald A. Rosenthal |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Antimetabolites
medicine.drug_class Lysine Biology Antimetabolite General Biochemistry Genetics and Molecular Biology Butyric acid chemistry.chemical_compound Oximes Tumor Cells Cultured medicine Animals Humans Enzyme Inhibitors General Pharmacology Toxicology and Pharmaceutics Pyridoxal phosphate Structural analog chemistry.chemical_classification Plants Medicinal Natural product Aminobutyrates food and beverages Fabaceae General Medicine Antineoplastic Agents Phytogenic Diet Amino acid Enzyme chemistry Biochemistry Pyridoxal Phosphate Drug Screening Assays Antitumor |
| Zdroj: | Life Sciences. 60:1635-1641 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/s0024-3205(96)00595-4 |
| Popis: | L-Canaline, the L-2-amino-4-(aminooxy)butyric acid structural analog of L-ornithine' is a powerful antimetabolite stored in many leguminous plants. This nonprotein amino acid reacts vigorously with the pyridoxal phosphate moiety of vitamin B6-containing enzymes to form a covalently-bound oxime that inactivates, often irreversibly, the enzyme. Canaline is not only capable of inhibiting ornithine-dependent enzymic activity, but it also can function as a lysine antagonist. Recently, this natural product was found to possess significant antineoplastic in vitro activity against human pancreatic cancer cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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