Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 1: Weakly basic azoles

Autor:	S. Dale Lewis, Adel M. Naylor-Olsen, Julie A. Krueger, Richard C.A. Isaacs, Mark G. Solinsky, Christina L. Newton, Kellie J. Cutrona, Bobby J. Lucas
Rok vydání:	2005
Předmět:	Azoles Stereochemistry Clinical Biochemistry Pharmaceutical Science Ligands Biochemistry Chemical synthesis chemistry.chemical_compound Structure-Activity Relationship Thrombin Drug Discovery medicine Peptide synthesis Structure–activity relationship Trypsin Enzyme Inhibitors Molecular Biology Alkyl chemistry.chemical_classification Molecular Structure Ligand Organic Chemistry Small molecule Sulfonamide chemistry Drug Design Molecular Medicine medicine.drug
Zdroj:	Bioorganicmedicinal chemistry letters. 16(2)
ISSN:	0960-894X
Popis:	Despite their relatively weak basicity, simple azoles, specifically imidazoles and aminothiazoles, can function as potent surrogates for the more basic amines (e.g., alkyl amines, amidines, guanidines, etc.) which are most often employed as the P1 ligand in the design of noncovalent small molecule inhibitors of thrombin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af8e469e2155418440af8bcabf0ead4a https://pubmed.ncbi.nlm.nih.gov/16257203 Zobrazit plný text záznamu Full Text from ScienceDirect