| Autor: |
Marc R. Dweck, David E. Newby, A. White, Hamish Richardson, James H.F. Rudd, Alison Fletcher, Charlotte Jones, Graham McKillop, Mlchelle C. Williams, Edwin Jacques Rudolph van Beek, Nicholas A. Boon, N Joshi, Marcus W. L. Chow |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Journal of the American College of Cardiology. 59(13) |
| ISSN: |
0735-1097 |
| DOI: |
10.1016/s0735-1097(12)62142-1 |
| Popis: |
Results: Repeatability statistics for the measurement of the coronary 18F-NaF uptake (max TBR) were excellent (intra-class coeficient 0.99). Activity was higher in patients with coronary atherosclerosis versus controls (1.64±0.49 vs 1.23±0.24; p 1000 displayed normal uptake. Patients with increased coronary 18F-NaF (n=40) had higher rates of prior cardiovascular events (P=0.02) and angina (p=0.02) and higher Framingham risk scores (P=0.01). By contrast quantiication of coronary 18F-FDG activity was hampered by myocardial uptake and not increased in those with atherosclerosis versus controls (p=0.50). Conclusion: 18F-NaF is a promising new approach for the assessment of coronary plaque biology and appears to be a novel marker of vulnerability, recent plaque rupture and cardiovascular risk |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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