Regional cerebral gray matter atrophy is associated with cognitive impairment in hemodialysis patients: a cross-sectional and longitudinal voxel-based morphological MRI study
| Autor: | Lei Liu, Xianchang Zhang, Shuang Xia, Tong Zhang, Jinping Li, Shen Wen, Gemuer Wu, Lixiang Huang, Chao Chai, Huiying Wang, Jinxia Zhu |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Cognitive Neuroscience computer.software_genre Behavioral Neuroscience Cellular and Molecular Neuroscience Atrophy Text mining Voxel Renal Dialysis medicine Humans Radiology Nuclear Medicine and imaging Cognitive Dysfunction Gray Matter Cognitive impairment business.industry Neurodegenerative Diseases medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Cross-Sectional Studies Neurology Cerebral gray matter Radiology Hemodialysis Neurology (clinical) business computer |
| Zdroj: | Brain imaging and behavior. 16(3) |
| ISSN: | 1931-7565 |
| Popis: | To explore changes of cerebral gray matter volumes (GMV) in hemodialysis patients, the clinical risk factors for GMV changes, and the relationship between GMV changes and neuropsychological tests results. Eighty-eight hemodialysis patients and seventy-six healthy controls (HCs) were recruited in this study. Fifty patients underwent follow-up magnetic resonance, blood biochemical examinations, and neuropsychological test (1.75±0.55 years). Changes in GMV between patients and HCs, longitudinal GMV changes in patients were explored. The clinical risk factors for the longitudinal GMV changes, the correlations between longitudinal GMV changes and neuropsychological tests changes in hemodialysis patients were analyzed. Compared to HCs, the hemodialysis patients had diffusely decreased in GMV (with age, sex, and total intracranial volume [TIV] as covariates, PPPPP=0.02). The decreased left caudate volumes were positively correlated with reduced MMSE scores in hemodialysis patients (rs=0.437, P=0.033). Hemodialysis patients had diffused GM atrophy over time, which was related to cognitive impairment. |
| Databáze: | OpenAIRE |
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