Lean body mass accretion is elevated in response to dietary vitamin D: A dose–response study in female weanling rats
| Autor: | Maryam Razaghi, Hope A. Weiler, Paula Lavery, Marija Djekic-Ivankovic, Sherry Agellon, Ivy L. Mak |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Leptin
0301 basic medicine Vitamin medicine.medical_specialty Endocrinology Diabetes and Metabolism Weanling 030209 endocrinology & metabolism Weaning Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Blood serum Internal medicine Vitamin D and neurology Animals Medicine Insulin-Like Growth Factor I Vitamin D Calcifediol Cholecalciferol 2. Zero hunger 030109 nutrition & dietetics Nutrition and Dietetics business.industry Diet Rats 3. Good health Insulin-Like Growth Factor Binding Protein 3 chemistry Dietary Supplements Body Composition Lean body mass Female medicine.symptom business Weight gain Hormone |
| Zdroj: | Nutrition Research. 68:92-100 |
| ISSN: | 0271-5317 |
| Popis: | Vitamin D status positively relates to lean body mass in infants. This study tested the effect of vitamin D on body composition and growth-related hormones. It was hypothesized that low vitamin D status programs for higher fat mass accretion. Female weanling Sprague–Dawley rats (4 weeks; n = 6/diet) were randomized to AIN-93G diets with modified vitamin D contents for 8 weeks: group 1 (1 IU vitamin D3/g diet), group 2 (2 IU vitamin D3/g diet), and group 3 (4 IU vitamin D3/g diet). At week 0, 4, and 8 of study, measurements included: serum 25(OH)D3, IGF-1, IGFBP3, leptin, and whole body composition assessed with DXA. Differences among groups were tested using mixed model ANOVA with Tukey's post hoc t-tests. No differences were observed in baseline body composition and biomarkers, nor did body weight and food intake differ over the study. At week 8, serum 25(OH)D3 in group 3 was higher (P |
| Databáze: | OpenAIRE |
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