Hyperphosphatasemia and concurrent adrenal gland dysfunction in apparently healthy Scottish Terriers
| Autor: | David L. Panciera, Kurt L. Zimmerman, Walter E. Hoffmann, Daniel C. Randall, Roger J. Panciera, Joseph H. Kinnarney, Jack W. Oliver, Ellen M. Binder |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Adrenocortical Hyperfunction medicine.drug_class Biology chemistry.chemical_compound Dogs Blood serum Adrenocorticotropic Hormone Internal medicine medicine Animals Genetic Predisposition to Disease Dog Diseases Hydrocortisone Aldosterone General Veterinary medicine.diagnostic_test Adrenal gland Hyperphosphatemia medicine.anatomical_structure Endocrinology Blood chemistry chemistry Liver biopsy Corticosteroid Female Liver function medicine.drug |
| Zdroj: | Journal of the American Veterinary Medical Association. 237:178-186 |
| ISSN: | 0003-1488 |
| DOI: | 10.2460/javma.237.2.178 |
| Popis: | Objective—To determine causes of hyperphosphatasemia (high serum alkaline phosphatase [ALP] activity) in apparently healthy Scottish Terriers. Design—Prospective case-controlled study. Animals—34 apparently healthy adult Scottish Terriers (17 with and 17 without hyperphosphatasemia). Procedures—Serum activities for 3 isoforms (bone, liver, and corticosteroid) of ALP were measured. Concentrations of cortisol, progesterone, 17-hydroxyprogesterone, androstenedione, estradiol, and aldosterone were measured before and after cosyntropin administration (ie, ACTH; 5 μg/kg [2.27 μg/lb], IM). Liver biopsy specimens from 16 dogs (11 with and 5 without hyperphosphatasemia) were evaluated histologically. Results—In dogs with hyperphosphatasemia, the corticosteroid ALP isoform comprised a significantly higher percentage of total ALP activity, compared with the percentage in dogs without hyperphosphatasemia (mean ± SE, 69 ± 5.0% and 17 ± 3.8%, respectively). In 6 dogs with hyperphosphatasemia, but none without, serum cortisol concentrations exceeded reference intervals after ACTH stimulation. Six dogs with and 15 without hyperphosphatasemia had increased concentrations of ≥ 1 noncortisol steroid hormone after ACTH stimulation. Serum ALP activity was correlated with cortisol and androstenedione concentrations (r = 0.337 and 0.496, respectively) measured after ACTH stimulation. All dogs with and most without hyperphosphatasemia had abnormal hepatocellular reticulation typical of vacuolar hepatopathy. Subjectively, hepatocellular reticulation was more severe and widespread in hyperphosphatasemic dogs, compared with that in nonhyperphosphatasemic dogs. Conclusions and Clinical Relevance—Hyperphosphatasemia in apparently healthy Scottish Terriers was most likely attributable to hyperadrenocorticism on the basis of exaggerated serum biochemical responses to ACTH administration and histologic hepatic changes, but none of the dogs had clinical signs of hyperadrenocorticism. |
| Databáze: | OpenAIRE |
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