A facile injectable carbon dot/oxidative polysaccharide hydrogel with potent self-healing and high antibacterial activity
| Autor: | Xiaodong Xing, Peili Li, Meizhe Yu, Shoukang Du, Haojie Lu, Huaping Tan, Xu Yang, Wentao Tang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Staphylococcus aureus
Polymers and Plastics 02 engineering and technology Oxidative phosphorylation 010402 general chemistry Polysaccharide complex mixtures 01 natural sciences chemistry.chemical_compound Materials Chemistry Humans Severe pain Polylysine chemistry.chemical_classification Wound Healing Carbon dot Organic Chemistry Dextrans Hydrogels Bacterial Infections 021001 nanoscience & nanotechnology Carbon Anti-Bacterial Agents 0104 chemical sciences Dextran chemistry Self-healing Nanoparticles 0210 nano-technology Antibacterial activity Wound healing Nuclear chemistry |
| Zdroj: | Carbohydrate Polymers. 251:117040 |
| ISSN: | 0144-8617 |
| DOI: | 10.1016/j.carbpol.2020.117040 |
| Popis: | Bacterial infection is one of the most formidable problems in wound healing, which inflicts severe pain on patients while causing wound ulceration. Here, we prepared an injectable self-healing carbon dot hydrogel with outstanding antibacterial activity only using e-poly(L-lysine) carbon dot (PL-CD) and oxidized dextran (ODA). The particle size of PL-CD prepared by pyrolysis of poly-l-lysine was about 3 nm. Moreover, PL-CD with abundant -NH2 on its surface could not only act as nodes to connect ODA through Schiff base to construct PL-CD@ODA hydrogel network, but also offer excellent antibacterial properties. As the contacting and releasing antibacterial action of the PL-CD@ODA hydrogel, nearly 100 % of the 107 CFU/mL of S. aureus was killed after 10 min of contacting. In addition, PL-CD@ODA hydrogel showed flexible injectability and extremely strong self-healing properties after being severely damaged. When 1000 % shear stress applied to the hydrogel, complete healing could be achieved within a few seconds. |
| Databáze: | OpenAIRE |
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