Mother-to-child HIV and HHV-8 transmission in neonates at Saint Camille Medical Centre in Burkina Faso
| Autor: | Salvatore Pignatelli, Pietra, D. Ilboudo, Silvia Odolini, F. Buelli, Jacques Simpore, D. Ouermi, Sia Dj, D. S. Karou, Cyrille Bisseye, Drissa Sanou, Tani Sagna, Charlemagne Gnoula, Jean-Baptiste Nikiema, Francesco Castelli |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
medicine.medical_specialty Nevirapine Cross-sectional study Anti-HIV Agents viruses Population HIV Infections Polymerase Chain Reaction Zidovudine Young Adult Acquired immunodeficiency syndrome (AIDS) Pregnancy Burkina Faso medicine Childbirth Humans Pregnancy Complications Infectious education education.field_of_study business.industry Obstetrics Infant Newborn virus diseases Lamivudine Herpesviridae Infections medicine.disease Virology Infectious Disease Transmission Vertical CD4 Lymphocyte Count Sexual abuse DNA Viral Herpesvirus 8 Human HIV-1 Female business Agronomy and Crop Science medicine.drug |
| Zdroj: | Pakistan journal of biological sciences : PJBS. 12(12) |
| ISSN: | 1028-8880 |
| Popis: | In Sub-Saharan Africa, many HIV infected people are co-infected with Human Herpes Virus 8 (HHV-8). Therefore, the present study aimed to: (1) identify the pregnant women co-infected by HIV and HHV-8 at Saint Camille Medical Centre; (2) use three molecules (Zidovudine, Nevirapine and Lamivudine) to interrupt the vertical transmission of HIV and (3) use the PCR technique to diagnose children, who were infected by these viruses, in order to offer them an early medical assistance. A total of 107 pregnant women, aged from 19 to 42 years were diagnosed to be HIV positive at Saint Camille Centre; among them 13 were co-infected with HHV-8. All included women received the HAART. Two to six months after childbirth their babies underwent PCR diagnosis for HIV and HHV-8. The results revealed that, among these mothers, 68.2% were housewives, 34.6% were illiterates and 60.7% did not have university degree. The prevalence of HHV-8 among these pregnant women was 12.15% and the rate of vertical transmission of both HIV and HHV-8, was 0.0%. The issue of this study revealed that the antiretroviral therapy increased the mother CD4 T-cells, prevented the transcription of the mRNA of HHV-8 and blocked HIV vertical transmission. |
| Databáze: | OpenAIRE |
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