EFFICACY OF COMBINED ANTIHYPERTENSIVE THERAPY IN ACHIEVEMENT OF TARGET BLOOD PRESSURE IN DIABETIC PATIENTS
| Autor: | O. A. Koshel'skaya, O. A. Zhuravleva, Karpov Rs |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Vascular wall
lcsh:Diseases of the circulatory (Cardiovascular) system medicine.medical_specialty arterial hypertension medicine.drug_class Calcium channel blocker RM1-950 артериальная гипертония combined therapy Internal medicine Diabetes mellitus medicine Diseases of the circulatory (Cardiovascular) system Pharmacology (medical) Amlodipine комбинированная терапия Glycemic сахарный диабет business.industry lcsh:RM1-950 Indapamide Insulin sensitivity medicine.disease lcsh:Therapeutics. Pharmacology Endocrinology Blood pressure lcsh:RC666-701 RC666-701 diabetes mellitus Cardiology Therapeutics. Pharmacology Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Racionalʹnaâ Farmakoterapiâ v Kardiologii, Vol 8, Iss 5, Pp 667-674 (2015) |
| ISSN: | 2225-3653 1819-6446 |
| Popis: | Aim. To evaluate the efficacy of long-term combined antihypertensive therapy (AHT) based on renin-angiotensin-aldosterone system (RAAS) blockers, indapamide and calcium channel blocker (CCB) in hypertensive patients with diabetes mellitus (DM) in accordance with target blood pressure (BP) 150 mm Hg (office) or >134 mmHg (ABPM). Marked beneficial effect on the morphological and functional characteristics of the vascular wall and its elastic properties, improvement of glycemic control, tissue insulin sensitivity and lipids profile were found. These effects were associated mainly with amlodipine inclusion into the therapy. Conclusion. The combined AHT based on RAAS blockers, indapamide SR and CCB provides achievement of target BP in the most of hypertensive patients with DM and accompanied by positive changes in vascular remodeling and metabolism. |
| Databáze: | OpenAIRE |
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