Gut microbiota in adolescent girls with polycystic ovary syndrome: Effects of randomized treatments
| Autor: | Desiree Henares, Rita Malpique, Belén Carbonetto, Abel López-Bermejo, Pedro González-Torres, Lourdes Ibáñez, Francis de Zegher, Carmen Muñoz-Almagro, Cristina Garcia-Beltran, Pedro Brotons |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adolescent Physiology 030209 endocrinology & metabolism Prevotellaceae Gut flora Spironolactone 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Prevotella Humans 030109 nutrition & dietetics Nutrition and Dietetics biology Pioglitazone business.industry Health Policy Public Health Environmental and Occupational Health medicine.disease biology.organism_classification Obesity Polycystic ovary Metformin Gastrointestinal Microbiome chemistry Pediatrics Perinatology and Child Health Female business Body mass index medicine.drug Polycystic Ovary Syndrome |
| Zdroj: | Pediatric obesityREFERENCES. 16(4) |
| ISSN: | 2047-6310 |
| Popis: | BACKGROUND Girls with obesity and polycystic ovary syndrome (PCOS) and women with PCOS have altered gut microbiota. OBJECTIVE To study the gut microbiota composition of girls with PCOS without obesity (age, 15.8 years; body mass index [BMI] 25 kg/m2 ) and the effects of randomized treatments with an oral contraceptive (OC, N = 15) or with spironolactone-pioglitazone-metformin (SPIOMET, N = 15) for 1 year. Thirty-one age-matched girls served as controls. METHODS 16S ribosomal subunit gene amplicon sequencing was performed in stool samples from all subjects; samples from 23 out of 30 girls with PCOS (OC, N = 12; SPIOMET, N = 11) were available for analysis post-treatment. Clinical and endocrine-metabolic variables were measured before and after intervention. RESULTS Girls with PCOS had decreased diversity alpha, altered microbiota pattern and taxonomic profile with more abundance of Family XI (P = .002), and less abundance of family Prevotellaceae (P = .0006) the genus Prevotella (P = .0001) and Senegalimassilia (P |
| Databáze: | OpenAIRE |
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