Botanic Origin of Propolis Extract Powder Drives Contrasted Impact on Diabesity in High-Fat-Fed Mice
| Autor: | Charlène Couturier, Lourdes Mounien, Nicolas Cardinault, Claire Letullier, Jean-François Landrier, Franck Tourniaire, Lauriane Bonnet, Naïma Dlalah, Eva M. Seipelt, Stéphane Georgé, Esma Karkeni, Julien Astier |
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| Přispěvatelé: | Pollenergie, Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Génétique et Amélioration des Fruits et Légumes (GAFL), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Technique de la Conservation des Produits Agricoles, Criblage biologique Marseille [Faculté de médecine de la Timone], Centre Technique de la Conservation des Produits Agricole, Site Agroparc (CTCPA), Lucas, Nelly |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
obesity Antioxidant Physiology glucose tolerance medicine.medical_treatment Clinical Biochemistry Adipose tissue 030209 endocrinology & metabolism Biochemistry Article 03 medical and health sciences 0302 clinical medicine Nutraceutical [SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular Biology medicine Glucose homeostasis [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Food science Molecular Biology biology Baccharis lcsh:RM1-950 adipose tissue.glucose tolerance.obesitypropolis.preventive nutrition Cell Biology Propolis preventive nutrition biology.organism_classification medicine.disease Obesity adipose tissue propolis 030104 developmental biology lcsh:Therapeutics. Pharmacology Polyphenol obesitypropolis |
| Zdroj: | Antioxidants, Vol 10, Iss 411, p 411 (2021) Antioxidants Volume 10 Issue 3 Antioxidants, MDPI, 2021, 10 (3), pp.1-15. ⟨10.3390/antiox10030411⟩ Antioxidants, MDPI, 2021, 10 (3), pp.411. ⟨10.3390/antiox10030411⟩ Antioxidants, 2021, 10 (3), pp.411. ⟨10.3390/antiox10030411⟩ |
| ISSN: | 2076-3921 |
| Popis: | Propolis extracts are considered as nutraceutical products with potentialities towards obesity and comorbidities management. Nevertheless, propolis extracts composition is highly variable and depends on the botanic origin of plants used by the bees to produce propolis. This study aims to evaluate the differential effect of poplar propolis extract powder (PPEP), Baccharis propolis extract powder (BPEP), and/ or Dalbergia propolis extract powder (DPEP) on obesity and glucose homeostasis in high-fat-fed mice. PPEP supplementation reduced high-fat (HF)-mediated body weight gain, adiposity index, and improved glucose homeostasis in male C57Bl/6J mice that were submitted to a high-fat diet for 12 weeks, whereas BPEP, DPEP, or a mix of the three PEPs did not modify those parameters. Adipose tissue (AT) gene expression profiling highlighted an induction of mRNA related to lipid catabolism and an inhibition of mRNA coding for inflammatory markers. Several Nrf2 target genes, coding for antioxidant enzymes, were induced in AT under PPEP effect, but not by other PEP. Interestingly, representative PPEP polyphenols mediated the induction of Nrf2 target genes cell-autonomously in adipocytes, suggesting that this induction may be related to the specific polyphenol content of PPEP. Whereas PPEP supplementation has demonstrated a clear potential to blunt the onset of obesity and associated comorbidities, other PEPs (from Baccharis and Dalbergia) were inefficient to support their role in preventive nutrition. |
| Databáze: | OpenAIRE |
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