Evidence of chronic stroke rehabilitation interventions in activities and participation outcomes: systematic review of meta-analyses of randomized controlled trials
| Autor: | Alejandro García-Rudolph, Josep Maria Tormos, Eloy Opisso, Sara Laxe, Montserrat Bernabeu, Joan Saurí |
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| Rok vydání: | 2020 |
| Předmět: |
Gerontology
030506 rehabilitation Activities of daily living medicine.medical_treatment Psychological intervention MEDLINE Physical Therapy Sports Therapy and Rehabilitation law.invention Disability Evaluation 03 medical and health sciences 0302 clinical medicine Quality of life (healthcare) Meta-Analysis as Topic International Classification of Functioning Disability and Health Randomized controlled trial law Activities of Daily Living Humans Medicine Randomized Controlled Trials as Topic Rehabilitation business.industry Stroke Rehabilitation Exercise Therapy Systematic review Chronic Disease Quality of Life 0305 other medical science business 030217 neurology & neurosurgery |
| Zdroj: | Eur J Phys Rehabil Med. |
| ISSN: | 1973-9095 1973-9087 |
| Popis: | INTRODUCTION Stroke is a leading cause of long-term disabilities worldwide. A great deal of meta-analyses of randomized controlled trials (RCTs) address rehabilitation in chronic stroke, several of them with focus on activities and participation, considered critical outcomes of successful rehabilitation. Nevertheless, substantial heterogeneity might exist between studies, the reported associations may be causal, but they might also be flawed, as inherent study biases such as residual confounding and selective reporting of positive results may exaggerate the effect of interventions in chronic phase. Furthermore, most RCTs might focus on specific rehabilitation domains, not paying the same attention to others. EVIDENCE ACQUSITION Formal evaluation of published systematic reviews of meta-analyses (January 2008 to November 2018) of rehabilitation in chronic phase to 1) assess the strength of evidence: participants, publication biases, heterogeneity, prediction intervals (PIs) 2) grade the evidence to perform qualitative analysis on effects sizes and heterogeneity, 3) perform meta-regressions and sensitivity analysis on relevant covariates 4) map outcomes to activities and participation domain of the World Health Organization's International Classification of Functioning, Disability and Health (ICF). Systematic review on meta-analyses of RCTs addressing activities and participation will be performed in Medline, Web of Science, Scopus, Cochrane and Google Scholar. EVIDENCE SYNTHESIS A total of 97 meta-analyses on 31 different rehabilitation interventions involving 25,275 participants were included. Thirty-nine meta-analyses (40.74%) reported statistically significant findings (P |
| Databáze: | OpenAIRE |
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